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Mieloma Multiplo

PALUMBO Prof. Antonio

 LAROCCA Dott. Alessandra

Biologia delle Cellule Staminali Epiteliali

CALAUTTI Dott. Vincenzo

Bionformatica e Genomica (B&Gu)

CALOGERO Prof. Raffaele Adolfo  

Caratteristiche cellulari e leucemia linfatica cronica (LLC)

COSCIA Dott. Marta

Cellule staminali pluripotenti (GPSC)

Fiorella Prof. Altruda
Sharmila Fagoonee
Elvira Famulari

 

Cellule staminali renali ed epatiche

Benedetta Bussolati

Stefania Bruno

Chimica Farmaceutica

T Potter, G Ermondi, G Newbury, G Caron (2015)
HT Caco-2 permeability: the dominant role played by solutes' hydrogen bonding donor properties.
https://iris.unito.it/handle/2318/1508134

Ermondi, G, Catalano, F , Vallaro, M , Ermondi, I , Leal, M P Camacho, Rinaldi, L , Visentin, S , Caron, G (2015)
Lipophilicity of amyloid beta-peptide 12-28 and 25-35 to unravel their ability to promote hydrophobic and electrostatic interactions.
https://iris.unito.it/handle/2318/1526253

G Ermondi, A Visconti, R Esposito, G Caron (2014)
The Block Relevance (BR) analysis supports the dominating effect of solutes hydrogen bond acidity on Deltalog Poct-tol
https://iris.unito.it/handle/2318/143546

Sonja Visentin, Maura Vallaro, Maria del Pilar Camacho, Claudio Medana, Giuseppe Ermondi, Giulia Caron (2014)
SYNTHESIS, LIPOPHILICITY AND PERMEABILITY OF CYCLIC HEXAPEPTIDES AS MODELS TO DISCOVER NEW CELL PENETRATING PEPTIDES (CPPS).
https://iris.unito.it/handle/2318/150567

M Shalaeva, G Caron, Y A Abramov, T N O'Connell, M S Plummer, G Yalamanchi, K A Farley, G H Goetz, L Philippe, M J Shapiro ? (2013)
Integrating Intramolecular Hydrogen Bonding (IMHB) Considerations in Drug Discovery Using DeltalogP As a Tool.
https://iris.unito.it/handle/2318/143547

Visentin S, Ermondi G, Vallaro M, Scalet G, Caron G (2013)
Blended-learning for courses in Pharmaceutical Analysis. Part 2.
https://iris.unito.it/handle/2318/128301

Controllo trascrizionale in infiammazione, autoimmunità e tumorigenesi

POLI Prof. Valeria  

 

 

Genetica dello Sviluppo

MERLO Prof. Giorgio Roberto

Genetica ed immunoterapia del cancro

Roberto prof. Chiarle

Genomica Funzionale

Roberto Prof. Piva

  1. Crescenzo R, Abate F, Lasorsa E, Tabbo F, Gaudiano M, Chiesa N, Di Giacomo F, Spaccarotella E, Barabarossa L, Ercole E, Todaro M, Boi M, Acquaviva A, Ficcara E, Novero D, Rinaldi A, Tousseyn T, Rosenwald A, Kenner L, Cerroni L, Ponzoni M, Paulli M, Chan WC, Iqbal J, Piris MA, Ciardullo C, Rossi D, Gaidano G, Pileri S, Tiacci E, Falini B, Shultz LD, Vialard JE, Piva R, Bertoni F, Rabadan R, Inghirami G. Convergent alternations or new kinase fusions lead to oncogenic STAT3 activation in Anaplastic Large Cell Lymphoma. In Press: CANCER CELL 2015
  2. Abate F, Todaro M, van der Krogt JA, Boi M, Landra I, Machiorlatti R, Tabbò F, Messana K, Abele C, Barreca A, Novero D, Gaudiano Aliberti S, Di Giacomo F, Tousseyn T, Lasorsa E, Crescenzo R, Bessone L, Ficarra E, Acquaviva A, Rinaldi A, Ponzoni M, Longo DL, Aime S, Cheng M, Ruggeri B, Piccaluga PP, Pileri S, Tiacci E, Falini B, Pera-Gresely B, Cerchietti L, Iqbal J, Chan WC, Shultz LD, Kwee I, Piva R, Wlodarska I, Rabadan R, Bertoni F, Inghirami G; The European T-cell Lymphoma Study Group. A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. Leukemia. 2014 Dec 23. PubMed PMID: 25533804.
  3. Piva R, Deaglio S, Famà R, Buonincontri R, Scarfò I, Bruscaggin A, Mereu E, Serra S, Spina V, Brusa D, Garaffo G, Monti S, Dal Bo M, Marasca R, Arcaini L, Neri A, Gattei V, Paulli M, Tiacci E, Bertoni F, Pileri SA, Foà R, Inghirami G, Gaidano G, Rossi D. The krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma. Leukemia. 2014 Oct 6;PubMed PMID: 25283840.
  4. Martinengo C, Poggio T, Menotti M, Scalzo MS, Ambrogio C, Mastini C, Pellegrino E, Riera L, Piva R, Ribatti D, Pastorino F, Perri P, Ponzoni M, Wang Q, Voena C, Chiarle R. ALK-dependent control of hypoxia inducible factors mediates tumor growth and metastasis. Cancer Res. 2014 Sep 5;PubMed PMID: 25193384
  5. Martinengo C, Poggio T, Menotti M, Scalzo MS, Ambrogio C, Mastini C, Pellegrino E, Riera L, Piva R, Ribatti D, Pastorino F, Perri P, Ponzoni M, Wang Q, Voena C, Chiarle R. ALK-dependent control of hypoxia inducible factors mediates tumor growth and metastasis. Cancer Res. 2014 Sep 5;PubMed PMID: 25193384
  6. Verdelli D, Nobili L, Todoerti K, Mosca L, Fabris S, D'Anca M, Pellegrino E, Piva R, Inghirami G, Capelli C, Introna M, Baldini L, Chiaramonte R, Lombardi L, Neri A. Molecular events underlying interleukin-6 independence in a subclone ofthe CMA-03 multiple myeloma cell line. Genes Chromosomes Cancer. 2014 Feb;53(2):154-67. doi: 10.1002/gcc.22127. Epub 2013 Nov 5. PubMed PMID: 24327544.
  7. Saoncella S, Tassone B, Deklic E, Avolio F, Jon C, Tornillo G, De Luca E, Di Iorio E, Piva R, Cabodi S, Turco E, Pandolfi PP, Calautti E. Nuclear Akt2 opposes limbal keratinocyte stem cell self-renewal by repressing a FOXO-mTORC1 signaling  pathway. Stem Cells. 2013 Oct 7. doi: 10.1002/stem.1565. [Epub ahead of print] PubMed PMID: 24123662.
  8. Abate F, Acquaviva A, Ficarra E, Piva R, Macii E. Gelsius: a literature-based  workflow for determining quantitative associations between genes and biological processes. IEEE/ACM Trans Comput Biol Bioinform. 2013 May-Jun;10(3):619-31. doi: 10.1109/TCBB.2013.11. PubMed PMID: 24091396.
  9. Boi M, Rinaldi A, Kwee I, Bonetti P, Todaro M, Tabbò F, Piva R, Rancoita PM, Matolcsy A, Timar B, Tousseyn T, Rodríguez-Pinilla SM, Piris MA, Beà S, Campo E, Bhagat G, Swerdlow SH, Rosenwald A, Ponzoni M, Young KH, Piccaluga PP, Dummer R,  Pileri S, Zucca E, Inghirami G, Bertoni F. PRDM1/BLIMP1 is commonly inactivated in anaplastic large T-cell lymphoma. Blood. 2013 Oct 10;122(15):2683-93. doi: 10.1182/blood-2013-04-497933. Epub 2013 Sep 4. PubMed PMID: 24004669.
  10. Spaccarotella E, Pellegrino E, Ferracin M, Ferreri C, Cuccuru G, Liu C, Iqbal  J, Cantarella D, Taulli R, Provero P, Di Cunto F, Medico E, Negrini M, Chan WC, Inghirami G, Piva R. STAT3-mediated activation of microRNA cluster 17~92 promotes proliferation and survival of ALK positive anaplastic large cell lymphoma. Haematologica. 2013 Aug 23. [Epub ahead of print] PubMed PMID: 23975180.
  11. Bonetti P, Testoni M, Scandurra M, Ponzoni M, Piva R, Mensah AA, Rinaldi A, Kwee I, Tibiletti MG, Iqbal J, Greiner TC, Chan WC, Gaidano G, Piris MA, Cavalli F, Zucca E, Inghirami G, Bertoni F. Deregulation of ETS1 and FLI1 contributes to  the pathogenesis of diffuse large B-cell lymphoma. Blood. 2013 Sep 26;122(13):2233-41. doi: 10.1182/blood-2013-01-475772. Epub 2013 Aug 7. PubMed PMID: 23926301.
  12. Peviani M, Tortarolo M, Battaglia E, Piva R, Bendotti C. Specific Induction of Akt3 in Spinal Cord Motor Neurons is Neuroprotective in a Mouse Model of Familial Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2013 Jul 20. [Epub ahead of print]  PubMed PMID: 23873136.
  13. Liu C, Iqbal J, Teruya-Feldstein J, Shen Y, Dabrowska MJ, Dybkaer K, Lim MS, Piva R, Barreca A, Pellegrino E, Spaccarotella E, Lachel CM, Kucuk C, Jiang CS, Hu X, Bhagavathi S, Greiner TC, Weisenburger DD, Aoun P, Perkins SL, McKeithan TW, Inghirami G, Chan WC. MicroRNA expression profiling identifies molecular signatures associated with anaplastic large cell lymphoma. Blood. 2013 Sep 19;122(12):2083-92. doi: 10.1182/blood-2012-08-447375. Epub 2013 Jun 25. PubMed PMID: 23801630; PubMed Central PMCID: PMC3778551.
  14. Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp  I, Artaker M, Lagger S, Turner SD, Pileri S, Piccaluga PP, Valent P, Messana K, Landra I, Weichhart T, Knapp S, Shehata M, Todaro M, Sexl V, Höfler G, Piva R, Medico E, Ruggeri BA, Cheng M, Eferl R, Egger G, Penninger JM, Jaeger U, Moriggl  R, Inghirami G, Kenner L. PDGFR blockade is a rational and effective therapy for  NPM-ALK-driven lymphomas. Nat Med. 2012 Nov;18(11):1699-704. doi: 10.1038/nm.2966. Epub 2012 Oct 14. PubMed PMID: 23064464.
  15. Tabbó F, Barreca A, Piva R, Inghirami G; European T-Cell Lymphoma Study Group. ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma. Front  Oncol. 2012 May 11;2:41. doi: 10.3389/fonc.2012.00041. eCollection 2012. PubMed PMID: 22649787; PubMed Central PMCID: PMC3355932.
  16. Tabbò F, Ponzoni M, Rabadan R, Bertoni F, Inghirami G; European T-cell Lymphoma Study Group. Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma. Curr Opin Hematol. 2013 Jul;20(4):374-81. doi: 10.1097/MOH.0b013e3283623c07. Review. PubMed PMID: 23673339.
  17. Peviani M, Kurosaki M, Terao M, Lidonnici D, Gensano F, Battaglia E, Tortarolo M, Piva R, Bendotti C. Lentiviral vectors carrying enhancer elements of Hb9 promoter drive selective transgene expression in mouse spinal cord motor neurons. J Neurosci Methods. 2012 Mar 30;205(1):139-47. doi: 10.1016/j.jneumeth.2011.12.024. Epub 2012 Jan 8. PubMed PMID: 22245491.
  18. Piva R, Agnelli L, Pellegrino E, Todoerti K, Grosso V, Tamagno I, Fornari A,  Martinoglio B, Medico E, Zamò A, Facchetti F, Ponzoni M, Geissinger E, Rosenwald  A, Müller-Hermelink HK, De Wolf-Peeters C, Piccaluga PP, Pileri S, Neri A, Inghirami G. Gene expression profiling uncovers molecular classifiers for the recognition of anaplastic large-cell lymphoma within peripheral T-cell neoplasms. J Clin Oncol. 2010 Mar 20;28(9):1583-90. doi: 10.1200/JCO.2008.20.9759. Epub 2010 Feb 16. PubMed PMID: 20159827.
  19. Belardo G, Piva R, Santoro MG. Heat stress triggers apoptosis by impairing NF-kappaB survival signaling in malignant B cells. Leukemia. 2010 Jan;24(1):187-96. doi: 10.1038/leu.2009.227. Epub 2009 Nov 19. PubMed PMID: 19924145.
  20. Regis G, Icardi L, Conti L, Chiarle R, Piva R, Giovarelli M, Poli V, Novelli  F. IL-6, but not IFN-gamma, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing. Leukemia. 2009 Nov;23(11):2102-8. doi: 10.1038/leu.2009.139. Epub 2009 Jul 23. PubMed PMID: 19626047.
  21. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, Bosco MC. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-2 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. J Leukoc Biol. 2008 Mar;83(3):648-62. Epub 2007 Dec 18. PubMed PMID: 18089854.
  22. Di Stefano P, Damiano L, Cabodi S, Aramu S, Tordella L, Praduroux A, Piva R,  Cavallo F, Forni G, Silengo L, Tarone G, Turco E, Defilippi P. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J. 2007 Jun 20;26(12):2843-55. Epub 2007 May 24. PubMed PMID: 17525734; PubMed Central PMCID: PMC1894765.
  23. Primo L, di Blasio L, Roca C, Droetto S, Piva R, Schaffhausen B, Bussolino F. Essential role of PDK1 in regulating endothelial cell migration. J Cell Biol. 2007 Mar 26;176(7):1035-47. Epub 2007 Mar 19. PubMed PMID: 17371830; PubMed Central PMCID: PMC2064087.
  24. Piva R, Pellegrino E, Mattioli M, Agnelli L, Lombardi L, Boccalatte F, Costa  G, Ruggeri BA, Cheng M, Chiarle R, Palestro G, Neri A, Inghirami G. Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB andBCL2A1 as critical target genes.  J Clin Invest. 2006 Dec;116(12):3171-82. Epub 2006 Nov 16. PubMed PMID: 17111047; PubMed Central PMCID: PMC1636692.
  25. Piva R, Chiarle R, Manazza AD, Taulli R, Simmons W, Ambrogio C, D'Escamard V, Pellegrino E, Ponzetto C, Palestro G, Inghirami G.  Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.  Blood. 2006 Jan 15;107(2):689-97. Epub 2005 Sep 27. PubMed PMID: 16189272; PubMed Central PMCID: PMC1895619.

Identificazione di sottotipi di Trombocitemia Essenziale

Achille Prof. Pich

Imaging Molecolare

AIME Prof. Silvio  

TERRENO Prof. Enzo

CUTRIN Dott. Juan Carlos

DASTRU' Dott. Walter

DELLI CASTELLI Dott. Daniela

REINERI Dott. Francesca

Mass Spectrometry Unit

BAIOCCHI Prof. Claudio

MEDANA Prof. Claudio

Meccanismi di cardioprotezione

Di Savino A, Panuzzo C, Rocca S, Familiari U, Piazza R, Crivellaro S, Carrà G, Ferretti R, Fusella F, Giugliano E, Camporeale A, Franco I, Miniscalco B, Cutrin JC, Turco E, Silengo L, Hirsch E, Rege-Cambrin G, Gambacorti-Passerini C, Pandolfi PP, Papotti M, Saglio G, Tarone G, Morotti A, Brancaccio M. Morgana acts as an oncosuppressor in chronic myeloid leukemia. Blood. 2015 Feb 12. pii:blood-2014-05-575001. [Epub ahead of print] PubMed PMID: 25678499.

Tarone G, Brancaccio M. The muscle-specific chaperone protein melusin is a potent cardioprotective agent. Basic Res Cardiol. 2015 Mar;110(2):10

Seano G, Chiaverina G, Gagliardi PA, di Blasio L, Puliafito A, Bouvard C, Sessa R, Tarone G, Sorokin L, Helley D, Jain RK, Serini G, Bussolino F, Primo L.  Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nat Cell Biol. 2014 Oct;16(10):931-41, 1-8. doi: 10.1038/ncb3036. Epub 2014 Sep 14. PubMed PMID: 25218639. 

Penna C, Brancaccio M, Tullio F, Rubinetto C, Perrelli MG, Angotti C, Pagliaro P, Tarone G. Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury. Basic Res Cardiol. 2014 Jul;109(4):418. doi: 10.1007/s00395-014-0418-9. Epub 2014 May 25. PubMed PMID: 24859929.  

Tarone G, Balligand JL, Bauersachs J, Clerk A, De Windt L, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Knöll R, Leite-Moreira AF, Lourenço AP, Mayr M, Thum T, Tocchetti CG. Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology. Eur J Heart Fail. 2014 May;16(5):494-508. doi: 10.1002/ejhf.62. Epub 2014 Mar 17. PubMed PMID: 24639064.  

Fusella F, Ferretti R, Recupero D, Rocca S, Di Savino A, Tornillo G, Silengo L, Turco E, Cabodi S, Provero P, Pandolfi PP, Sapino A, Tarone G, Brancaccio M. Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway. J Pathol. 2014 Oct;234(2):152-63. doi: 10.1002/path.4341. Epub 2014 Aug 6. PubMed PMID: 24615293.  

Tarone G, Brancaccio M. Keep your heart in shape: molecular chaperone networks for treating heart disease. Cardiovasc Res. 2014 Jun 1;102(3):346-61. doi: 10.1093/cvr/cvu049. Epub 2014 Feb 28. PubMed PMID: 24585203.  

Leite-Moreira AF, Lourenço AP, Balligand JL, Bauersachs J, Clerk A, De Windt LJ, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Kaminski KA, Knöll R, Mayr M, Tarone G, Thum T, Tocchetti CG. ESC Working Group on Myocardial Function  Position Paper: how to study the right ventricle in experimental models. Eur J Heart Fail. 2014 May;16(5):509-18. doi: 10.1002/ejhf.66. Epub 2014 Feb 23. PubMed PMID: 24574252.  

Hohl M, Ardehali H, Azuaje FJ, Breckenridge RA, Doehner W, Eaton P, Ehret GB,  Fujita T, Gaetani R, Giacca M, Hasenfuß G, Heymans S, Leite-Moreira AF, Linke WA, Linz D, Lyon A, Mamas MA, Orešič M, Papp Z, Pedrazzini T, Piepoli M, Prosser B, Rizzuto R, Tarone G, Tian R, van Craenenbroeck E, van Rooij E, Wai T, Weiss G, Maack C. Meeting highlights from the 2013 European Society of Cardiology Heart Failure Association Winter Meeting on Translational Heart Failure Research. Eur J Heart Fail. 2014 Jan;16(1):6-14. doi: 10.1002/ejhf.10. Epub 2013 Dec 14. Review.  PubMed PMID: 24453095.  

Unsöld B, Kaul A, Sbroggiò M, Schubert C, Regitz-Zagrosek V, Brancaccio M, Damilano F, Hirsch E, Van Bilsen M, Munts C, Sipido K, Bito V, Detre E, Wagner NM, Schäfer K, Seidler T, Vogt J, Neef S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura-Clapier R, Garnier A, Eschenhagen T, El-Armouche A, Knöll R, Tarone G, Hasenfuß G. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. Cardiovasc Res. 2014 Jan 1;101(1):97-107. doi: 10.1093/cvr/cvt235. Epub 2013 Oct 15. PubMed PMID: 24130190.  

Hirsch E, Hilfiker-Kleiner D, Balligand JL, Tarone G, De Windt L, Bauersachs J, Ferdinandy P, Davidson S, Hausenloy DJ, Schulz R. Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology. Cardiovasc Res. 2013 Sep 1;99(4):595-9. doi: 10.1093/cvr/cvt179. Epub 2013 Jul 16. PubMed PMID: 23860811.  

Tarone G, Sbroggiò M, Brancaccio M. Key role of ERK1/2 molecular scaffolds in heart pathology. Cell Mol Life Sci. 2013 Nov;70(21):4047-54. doi: 10.1007/s00018-013-1321-5. Epub 2013 Mar 27. Review. PubMed PMID: 23532408.  

Brizzi MF, Tarone G, Defilippi P. Extracellular matrix, integrins, and growth factors as tailors of the stem cell niche. Curr Opin Cell Biol. 2012 Oct;24(5):645-51. doi: 10.1016/j.ceb.2012.07.001. Epub 2012 Aug 13. Review. PubMed PMID: 22898530.  

Ferretti R, Sbroggiò M, Di Savino A, Fusella F, Bertero A, Michowski W, Tarone G, Brancaccio M. Morgana and melusin: two fairies chaperoning signal transduction. Cell Cycle. 2011 Nov 1;10(21):3678-83. doi: 10.4161/cc.10.21.18202. Epub 2011 Nov 1. Review. PubMed PMID: 22037254.  

Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M, Tarone G. ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. J Cell Sci. 2011  Oct 15;124(Pt 20):3515-24. doi: 10.1242/jcs.091140. PubMed PMID: 22010199; PubMed Central PMCID: PMC3706035.  

Knöll R, Iaccarino G, Tarone G, Hilfiker-Kleiner D, Bauersachs J, Leite-Moreira AF, Sugden PH, Balligand JL; European Society of Cardiology. Towards a re-definition of 'cardiac hypertrophy' through a rational characterization of left ventricular phenotypes: a position paper of the Working  Group 'Myocardial Function' of the ESC. Eur J Heart Fail. 2011 Aug;13(8):811-9. doi: 10.1093/eurjhf/hfr071. Epub 2011 Jun 27. PubMed PMID: 21708908.  

Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G. IQGAP1 regulates ERK1/2 and AKT signaling in the heart and sustains functional remodeling upon pressure overload. Cardiovasc Res. 2011 Apr 14. [Epub ahead of print] PubMed PMID: 21493702.

Palumbo V, Segat L, Padovan L, Amoroso A, Trimarco B, Izzo R, Lembo G, Regitz-Zagrosek V, Knoll R, Brancaccio M, Tarone G, Crovella S. Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients. BMC Med Genet. 2009 Dec 17;10:140.

Sbroggiò M, Ferretti R, Percivalle E, Gutkowska M, Zylicz A, Michowski W, Kuznicki J, Accornero F, Pacchioni B, Lanfranchi G, Hamm J, Turco E, Silengo L, Tarone G, Brancaccio M. The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. FEBS Lett. 2008 Jun 11;582(13):1788-94.

Brokat S, Thomas J, Herda LR, Knosalla C, Pregla R, Brancaccio M, Accornero F, Tarone G, Hetzer R, Regitz-Zagrosek V. Altered melusin expression in the hearts of aortic stenosis patients. Eur J Heart Fail. 2007 Jun-Jul;9(6-7):568-73.

Brancaccio M, Hirsch E, Notte A, Selvetella G, Lembo G, Tarone G. Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res. 2006 Jun 1;70(3):422-33.

Vecchione C, Aretini A, Marino G, Bettarini U, Poulet R, Maffei A, Sbroggiò M, Pastore L, Gentile MT, Notte A, Iorio L, Hirsch E, Tarone G, Lembo G. Selective Rac-1 inhibition protects from diabetes-induced vascular injury. Circ Res. 2006 Feb 3;98(2):218-25.

De Acetis M, Notte A, Accornero F, Selvetella G, Brancaccio M, Vecchione C, Sbroggiò M, Collino F, Pacchioni B, Lanfranchi G, Aretini A, Ferretti R, Maffei A, Altruda F, Silengo L, Tarone G, Lembo G. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res. 2005 May 27;96(10):1087-94.

Vecchione C, Patrucco E, Marino G, Barberis L, Poulet R, Aretini A, Maffei A, Gentile MT, Storto M, Azzolino O, Brancaccio M, Colussi GL, Bettarini U, Altruda F, Silengo L, Tarone G, Wymann MP, Hirsch E, Lembo G. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med. 2005 Apr 18;201(8):1217-28.

Selvetella G, Hirsch E, Notte A, Tarone G, Lembo G. Adaptive and maladaptive  hypertrophic pathways: points of convergence and divergence. Cardiovasc Res. 2004 Aug 15;63(3):373-80. Review.

Tarone G, Lembo G. Molecular interplay between mechanical and humoral signalling in cardiac hypertrophy. Trends Mol Med. 2003 Sep;9(9):376-82. Review.

Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De Acetis M,  Vecchione C, Marino G, Altruda F, Silengo L, Tarone G, Lembo G. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med. 2003 Jan;9(1):68-75.

Brancaccio M, Menini N, Bongioanni D, Ferretti R, De Acetis M, Silengo L, Tarone G. Chp-1 and melusin, two CHORD containing proteins in vertebrates. FEBS Lett. 2003 Sep 11;551(1-3):47-52.

Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea M, Rocchi M, Altruda F, Tarone G, Silengo L. Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. J Biol Chem. 1999 Oct 8;274(41):29282-8.

Cabodi S, Tinnirello A, Bisaro B, Tornillo G, del Pilar Camacho-Leal M, Forni  G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, Defilippi P. p130Cas is an essential transducer element in ErbB2 transformation. FASEB J. 2010 Oct;24(10):3796-808.

Michowski W, Ferretti R, Wisniewska MB, Ambrozkiewicz M, Beresewicz M, Fusella F, Skibinska-Kijek A, Zablocka B, Brancaccio M, Tarone G, Kuznicki J. Morgana/CHP-1 is a novel chaperone able to protect cells from stress. Biochim Biophys Acta. 2010 Sep;1803(9):1043-9.

Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M. Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. Dev Cell. 2010 Mar 16;18(3):486-95.

Di Stefano P, Damiano L, Cabodi S, Aramu S, Tordella L, Praduroux A, Piva R, Cavallo F, Forni G, Silengo L, Tarone G, Turco E, Defilippi P. p140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity. EMBO J. 2007 Jun 20;26(12):2843-55.

Boeri Erba E, Matthiesen R, Bunkenborg J, Schulze WX, Di Stefano P, Cabodi S,  Tarone G, Defilippi P, Jensen ON. Quantitation of multisite EGF receptor phosphorylation using mass spectrometry and a novel normalization approach. J Proteome Res. 2007 Jul;6(7):2768-85.

Cabodi S, Tinnirello A, Di Stefano P, Bisarò B, Ambrosino E, Castellano I, Sapino A, Arisio R, Cavallo F, Forni G, Glukhova M, Silengo L, Altruda F, Turco E, Tarone G, Defilippi P. p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis. Cancer Res. 2006 May 1;66(9):4672-80.

Ambrogio C, Voena C, Manazza AD, Piva R, Riera L, Barberis L, Costa C, Tarone G, Defilippi P, Hirsch E, Boeri Erba E, Mohammed S, Jensen ON, Palestro G, Inghirami G, Chiarle R. p130Cas mediates the transforming properties of the anaplastic lymphoma kinase. Blood. 2005 Dec 1;106(12):3907-16.
 
Defilippi P, Rosso A, Dentelli P, Calvi C, Garbarino G, Tarone G, Pegoraro L, Brizzi MF. {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and  anchorage-dependent proliferation. J Cell Biol. 2005 Mar 28;168(7):1099-108.

Di Stefano P, Cabodi S, Boeri Erba E, Margaria V, Bergatto E, Giuffrida MG, Silengo L, Tarone G, Turco E, Defilippi P. P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading. Mol Biol Cell. 2004 Feb;15(2):787-800.

Giancotti FG, Tarone G. Positional control of cell fate through joint integrin/receptor protein kinase signaling. Annu Rev Cell Dev Biol. 2003;19:173-206. Review. 
 

Meccanismi di trasporto di eme e emoproteine

TOLOSANO Prof. Emanuela

Meccanismi molecolari di tumorigenesi e progressione tumorale

Mara Prof. Brancaccio

Di Savino, A., Panuzzo, C., Rocca, S., Familiari, U., Piazza, R., Crivellaro, S., Carra, G., Ferretti, R., Fusella, F., Giugliano, E., Camporeale, A., Franco, I., Miniscalco, B., Cutrin, J.C., Turco, E., Silengo, L., Hirsch, E., Rege-Cambrin, G., Gambacorti-Passerini, C., Pandolfi, P.P., Papotti, M., Saglio, G., Tarone, G., Morotti, A. and Brancaccio, M. Morgana acts as an oncosuppressor in chronic myeloid leukemia. Blood (2015).

Tarone, G. and Brancaccio, M. The muscle-specific chaperone protein melusin is a potent cardioprotective agent. Basic Res Cardiol 110, 10 (2015).

Unsold, B., Kaul, A., Sbroggio, M., Schubert, C., Regitz-Zagrosek, V., Brancaccio, M., Damilano, F., Hirsch, E., Van Bilsen, M., Munts, C., Sipido, K., Bito, V., Detre, E., Wagner, N.M., Schafer, K., Seidler, T., Vogt, J., Neef, S., Bleckmann, A., Maier, L.S., Balligand, J.L., Bouzin, C., Ventura-Clapier, R., Garnier, A., Eschenhagen, T., El-Armouche, A., Knoll, R., Tarone, G. and Hasenfuss, G. Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction. Cardiovasc Res 101, 97-107 (2014).

Tarone, G. and Brancaccio, M. Keep your heart in shape: molecular chaperone networks for treating heart disease. Cardiovasc Res 102, 346-61 (2014).

Penna, C., Brancaccio, M., Tullio, F., Rubinetto, C., Perrelli, M.G., Angotti, C., Pagliaro, P. and Tarone, G. Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury. Basic Res Cardiol 109, 418 (2014).

Fusella, F., Ferretti, R., Recupero, D., Rocca, S., Di Savino, A., Tornillo, G., Silengo, L., Turco, E., Cabodi, S., Provero, P., Pandolfi, P.P., Sapino, A., Tarone, G. and Brancaccio, M. Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway. J Pathol 234, 152-63 (2014). 

Tarone, G., Sbroggio, M. and Brancaccio, M. Key role of ERK1/2 molecular scaffolds in heart pathology. Cell Mol Life Sci 70, 4047-54 (2013).

Waardenberg, A.J., Bernardo, B.C., Ng, D.C., Shepherd, P.R., Cemerlang, N., Sbroggio, M., Wells, C.A., Dalrymple, B.P., Brancaccio, M., Lin, R.C. and McMullen, J.R. Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure. J Biol Chem 286, 30837-46 (2011).

Sbroggio, M., Carnevale, D., Bertero, A., Cifelli, G., De Blasio, E., Mascio, G., Hirsch, E., Bahou, W.F., Turco, E., Silengo, L., Brancaccio, M., Lembo, G. and Tarone, G. IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload. Cardiovasc Res 91, 456-64 (2011).

Sbroggio, M., Bertero, A., Velasco, S., Fusella, F., De Blasio, E., Bahou, W.F., Silengo, L., Turco, E., Brancaccio, M. and Tarone, G. ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1. J Cell Sci 124, 3515-24 (2011).

Hanashiro, K., Brancaccio, M. and Fukasawa, K. Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification. Oncogene (2011).

12. Ferretti, R., Sbroggio, M., Di Savino, A., Fusella, F., Bertero, A., Michowski, W., Tarone, G. and Brancaccio, M. Morgana and melusin: two fairies chaperoning signal transduction. Cell Cycle 10, 3678-83 (2011).

Michowski, W., Ferretti, R., Wisniewska, M.B., Ambrozkiewicz, M., Beresewicz, M., Fusella, F., Skibinska-Kijek, A., Zablocka, B., Brancaccio, M., Tarone, G. and Kuznicki, J. Morgana/CHP-1 is a novel chaperone able to protect cells from stress. Biochim Biophys Acta (2010). 

Ferretti, R., Palumbo, V., Di Savino, A., Velasco, S., Sbroggio, M., Sportoletti, P., Micale, L., Turco, E., Silengo, L., Palumbo, G., Hirsch, E., Teruya-Feldstein, J., Bonaccorsi, S., Pandolfi, P.P., Gatti, M., Tarone, G. and Brancaccio, M. Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. Dev Cell 18, 486-95 (2010).

Palumbo, V., Segat, L., Padovan, L., Amoroso, A., Trimarco, B., Izzo, R., Lembo, G., Regitz-Zagrosek, V., Knoll, R., Brancaccio, M., Tarone, G. and Crovella, S. Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients. BMC Med Genet 10, 140 (2009).

Brancaccio, M., Turco, E. and Hirsch, E. Tissue-specific KO of ECM proteins. Methods Mol Biol 522, 15-50 (2009).

Sbroggio, M., Ferretti, R., Percivalle, E., Gutkowska, M., Zylicz, A., Michowski, W., Kuznicki, J., Accornero, F., Pacchioni, B., Lanfranchi, G., Hamm, J., Turco, E., Silengo, L., Tarone, G. and Brancaccio, M. The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1. FEBS Lett 582, 1788-94 (2008).

Volpe, G., Cignetti, A., Panuzzo, C., Kuka, M., Vitaggio, K., Brancaccio, M., Perrone, G., Rinaldi, M., Prato, G., Fava, M., Geuna, M., Pautasso, M., Casnici, C., Signori, E., Tonon, G., Tarone, G., Marelli, O., Fazio, V.M. and Saglio, G. Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res 67, 5300-7 (2007).

Brokat, S., Thomas, J., Herda, L.R., Knosalla, C., Pregla, R., Brancaccio, M., Accornero, F., Tarone, G., Hetzer, R. and Regitz-Zagrosek, V. Altered melusin expression in the hearts of aortic stenosis patients. Eur J Heart Fail 9, 568-73 (2007).

Brancaccio, M., Hirsch, E., Notte, A., Selvetella, G., Lembo, G. and Tarone, G. Integrin signalling: the tug-of-war in heart hypertrophy. Cardiovasc Res 70, 422-33 (2006).

Vecchione, C., Patrucco, E., Marino, G., Barberis, L., Poulet, R., Aretini, A., Maffei, A., Gentile, M.T., Storto, M., Azzolino, O., Brancaccio, M., Colussi, G.L., Bettarini, U., Altruda, F., Silengo, L., Tarone, G., Wymann, M.P., Hirsch, E. and Lembo, G. Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma. J Exp Med 201, 1217-28 (2005).

De Acetis, M., Notte, A., Accornero, F., Selvetella, G., Brancaccio, M., Vecchione, C., Sbroggio, M., Collino, F., Pacchioni, B., Lanfranchi, G., Aretini, A., Ferretti, R., Maffei, A., Altruda, F., Silengo, L., Tarone, G. and Lembo, G. Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload. Circ Res 96, 1087-94 (2005).

Patrucco, E., Notte, A., Barberis, L., Selvetella, G., Maffei, A., Brancaccio, M., Marengo, S., Russo, G., Azzolino, O., Rybalkin, S.D., Silengo, L., Altruda, F., Wetzker, R., Wymann, M.P., Lembo, G. and Hirsch, E. PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects. Cell 118, 375-87 (2004).

Brancaccio, M., Fratta, L., Notte, A., Hirsch, E., Poulet, R., Guazzone, S., De Acetis, M., Vecchione, C., Marino, G., Altruda, F., Silengo, L., Tarone, G. and Lembo, G. Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 9, 68-75 (2003).

Anastasi, G., Amato, A., Tarone, G., Vita, G., Monici, M.C., Magaudda, L., Brancaccio, M., Sidoti, A., Trimarchi, F., Favaloro, A. and Cutroneo, G. Distribution and localization of vinculin-talin-integrin system and dystrophin-glycoprotein complex in human skeletal muscle. Immunohistochemical study using confocal laser scanning microscopy. Cells Tissues Organs 175, 151-64 (2003).

Hirsch, E., Barberis, L., Brancaccio, M., Azzolino, O., Xu, D., Kyriakis, J.M., Silengo, L., Giancotti, F.G., Tarone, G., Fassler, R. and Altruda, F. Defective Rac-mediated proliferation and survival after targeted mutation of the beta1 integrin cytodomain. J Cell Biol 157, 481-92 (2002). 

Degani, S., Balzac, F., Brancaccio, M., Guazzone, S., Retta, S.F., Silengo, L., Eva, A. and Tarone, G. The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading. J Cell Biol 156, 377-87 (2002). 

Tarone, G., Hirsch, E., Brancaccio, M., De Acetis, M., Barberis, L., Balzac, F., Retta, S.F., Botta, C., Altruda, F. and Silengo, L. Integrin function and regulation in development. Int J Dev Biol 44, 725-31 (2000).

Hirsch, E., Brancaccio, M. and Altruda, F. Tissue-specific KO of ECM proteins. Methods Mol Biol 139, 147-78 (2000).

Barberis, L., Wary, K.K., Fiucci, G., Liu, F., Hirsch, E., Brancaccio, M., Altruda, F., Tarone, G. and Giancotti, F.G. Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK. J Biol Chem 275, 36532-40 (2000).

Brancaccio, M., Guazzone, S., Menini, N., Sibona, E., Hirsch, E., De Andrea, M., Rocchi, M., Altruda, F., Tarone, G. and Silengo, L. Melusin is a new muscle-specific interactor for b1 integrin cytoplasmic domain. J Biol Chem 274, 29282-8 (1999).

Brancaccio, M., Cabodi, S., Belkin, A.M., Collo, G., Koteliansky, V.E., Tomatis, D., Altruda, F., Silengo, L. and Tarone, G. Differential onset of expression of alpha 7 and beta 1D integrins during mouse heart and skeletal muscle development. Cell Adhes Commun 5, 193-205 (1998).

MicroRNA e adesione nella progressione tumorale

Daniela Taverna

  • Pinatel Eva Maria, Francesca Orso, Elisa Penna, Daniela Cimino, Angela Rita Elia, Paola Circosta, Patrizia Dentelli, Maria Felice Brizzi, Paolo Provero, Daniela Taverna. miR-223 is a coordinator of breast cancer progression as revealed by bioinformatics predictions. PLoS One 2014 Jan 6; 9(1).
  • E. Penna, F. Orso and D. Taverna. miR-214 as a key hub that controls cancer networks: small player, many functions. Journal of Investigative Dermatology, 2015 Apr;135(4):960-969. doi: 10.1038/jid.2014.479. Epub 2014 Dec 11.
  • Benjamin G. Cuiffo, Antoine Campagne, George W. Bell, Antonio Lembo, Francesca Orso, Evan C. Lien, Manoj K. Bhasin, Monica Raimo, Summer E. Hanson, Andriy Marusyk, Dorraya El-Ashry, Peiman Hematti, Kornelia Polyak, Fatima Mechta-Grigoriou, Odette Mariani, Stefano Volinia, Anne Vincent-Salomon, Daniela Taverna, Antoine E. Karnoub. MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer MetastasisCell Stem Cell, published online: October 16, 2014, Dec 4;15(6):762-74. 
  • A Petrelli, R Carollo, M Cargnelutti, F Iovino, M Callari, D Cimino, M Todaro, LR Mangiapane, A Giammona, A Cordova, F Montemurro, D Taverna, MG Daidone, G Stassi, S Giordano. MiR-100 sensitizes basal-like Breast Cancer Stem Cells to hormonal therapy via cell differentiation. Oncotarget, Feb 10;6(4):2315-30.
  • Penna E, Orso F, Cimino D, Vercellino I, Grassi E, Quaglino E, Turco E, Taverna DmiR-214 coordinates melanoma progression by upregulating ALCAM through TFAP2 and miR-148b downmodulation. Cancer Res. 2013 May 10. [Epub ahead of print]
  • Orso F, Balzac F, Marino M, Lembo A, Retta SF and Taverna D. . miR-21 coordinates tumor growth and modulates KRIT1 levels. Biochem Biophys Res Commun. 2013 Aug 16;438(1):90-6. doi: 10.1016/j.bbrc.2013.07.031. Epub 2013 Jul 18.
  • Pincini A*, Tornillo G*, Orso F,  Sciortino M,  Bisaro B, Camacho Leal MP, Lembo A, Brizzi MF, Turco E, De Pittà C, Provero P,  Medico E, DefilippI P,  Taverna D§ & Cabodi S§. Identification of p130Cas/ErbB2 dependent invasive signatures in transformed mammary epithelial cells. Cell Cycle. 2013 Aug 1;12(15):2409-22. doi: 10.4161/cc.25415. Epub 2013 Jun 28. § corresponding authors.
  • Barutta F, Tricarico M, Corbelli A, Annaratone L, Pinach S, Grimaldi S, Bruno G, Cimino D, Taverna D, Deregibus MC, Rastaldi MP, Perin PC, Gruden G. Urinary Exosomal MicroRNAs in Incipient Diabetic Nephropathy. PLoS One. 2013 Nov 4;8(11):e73798. Doi 10.1371/journal.pone.0073798.
  • Arigoni M, Barutello G, Riccardo F, Ercole E, Cantarella D, Orso F, Conti L, Lanzardo S, Taverna D, Merighi I, Calogero RA, Cavallo F, Quaglino E. miR-135b Coordinates Progression of ErbB2-Driven Mammary Carcinomas through Suppression of MID1 and MTCH2. Am J Pathol. 2013 Jun;182(6):2058-70.
  •  Elsarraj HS, Hong Y, Valdez K, Carletti M, Salah SM, Raimo M, Taverna D, Prochasson P, Bharadwaj U, Tweardy DJ, Christenson LK, Behbod F. Novel role of microRNA146b in promoting mammary alveolar progenitor cell maintenance.J Cell Sci. 2013 Apr 9. [Epub ahead of print]
  • D. Cimino, C. De Pittà, F. Orso, M. Zampini, S. Casara, E. Penna, E. Quaglino, M. Forni, C. Damasco, E. Pinatel, R. Ponzone, C. Romualdi, C. Brisken, M. De Bortoli, N. Biglia, P. Provero, G. Lanfranchi, D. Taverna (2012). miR148b is a major coordinator of breast cancer progression in a relapse-associated microRNA signature by targeting ITGA5, ROCK1, PIK3CA, NRAS and CSF1. THE FASEB JOURNAL, 2013 Mar;27(3):1223-35. doi: 10.1096/fj.12-214692. Epub 2012 Dec 11.
  • Bisaro B, Montani M, Konstantinidou G, Marchini C, Pietrella L, Iezzi M, Galie M, Orso F, Camporeale A, Colombo SM, Di Stefano P, Tornillo G, Camacho-Leal MD, Turco E, Taverna D, Cabodi S, Amici A, Defilippi P.p130Cas/Cyclooxygenase-2 axis in the control of mesenchymal plasticity of breast cancer cells. Breast Cancer Res. 2012 Oct 26;14(5):R137.
  • Osella-Abate S, Novelli M, Quaglino P, Orso F, Ubezio B, Tomasini C, Berardengo E, Bernengo MG, Taverna D.Expression of AP-2α, AP-2γ and ESDN in primary melanomas: Correlation with histopathological features and potential prognostic value. J Dermatol Sci. 2012 Dec;68(3):202-4. doi: 10.1016/j.jdermsci.2012.09.008. Epub 2012 Sep 18.
  • Gagliardi PA, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, Bussolino F, Primo L 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner. Neoplasia. 2012 Aug;14(8):719-31.
  • Courtin A, Communal L, Vilasco M, Cimino D, Mourra N, de Bortoli M, Taverna D, Faussat AM, Chaouat M, Forgez P, Gompel A. Glucocorticoid receptor activity discriminates between progesterone and medroxyprogesterone acetate effects in breast cells. Breast Cancer Res Treat. 2012 Jan;131(1):49-63. Epub 2011 Feb 19.
  • Tombolan L, Orso F, Guzzardo V, Casara S, Zin A, Bonora M, Romualdi C, Giorgi C, Bisogno G, Alaggio R, Pinton P, De Pittà C, Taverna D, Rosolen A, Lanfranchi G. High IGFBP2 expression correlates with tumor severity in pediatric rhabdomyosarcoma. Am J Pathol. 2011 Nov;179(5):2611-24. doi: 10.1016/j.ajpath.2011.07.018. Epub 2011 Sep 13.
  • Penna E, Orso F, Cimino D, Tenaglia E, Lembo A, Quaglino E, Poliseno L, Haimovic A, Osella-Abate S, De Pittà C, Pinatel E, Stadler MB, Provero P, Bernengo MG, Osman I, Taverna D. microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C. EMBO J. 2011 May 18;30(10):1990-2007. Epub 2011 Apr 5.
  • Friard O, Re A, Taverna D, De Bortoli M and Corà M. CircuitsDB: a database of mixed microRNA / Transcription. BMC Bioinformatics, 2010, 11:435-445. 
  • Dentelli P, Rosso A, Orso F, Taverna D and Maria Brizzi MF. miR-222 controls neovascularization by regulating STAT5A expression. Arteriosclerosis, Thrombosis and Vascular Biology, 2010, 30:1562-1568 
  • Orso F, Corà D, Ubezio B, De Bortoli M, Provero P, M. Caselle and Taverna D. Analysis of the regulatatory regions of AP-2amodulated genes. BMC Genomics, 2010, 11: 355. 
  • Cabodi S. and Taverna D. Interfering with inflammation: a new strategy to block breast cancer self-renewal and progression? Breast Cancer Research, 2010, 12:305. 
  • Thewes V, Orso F,  Jäger R, Eckert D, Kirfel G, Garbe G, Taverna D and Schorle H. Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation- sensitivity in breast cancer cells. BMC Cancer, 2010, 10:192
  • Orso F, Jaeger R, Calogero RA, Schorle H, Sismondi P, De Bortoli M and Taverna D. AP-2ALPHA REGULATES MIGRATION OF GN-11 NEURONS VIA A SPECIFIC GENETIC PROGRAM INVOLVING THE AXL RECEPTOR TYROSINE KINASE. BMC Biology, 2009, 7:25.
  • Re A, Corà D, Taverna D and Caselle M. GENOME WIDE SURVEY OF MICRO RNA-TRANSCRIPTION FACTOR REGULATORY CIRCUITS IN HUMAN. Mol. BioSyst., 2009, 5: 854-867.
  • Dentelli P, Trombetta A, Togliatto G, Zeoli A, Rosso A, Uberti B, Orso F, Taverna D, Pegoraro L, Brizzi MF. FORMATION OF STAT5/PPAR{GAMMA} TRANSCRIPTIONAL COMPLEX MODULATES ANGIOGENIC CELL BIOAVAILABILITY IN DIABETES. Arterioscler Thromb Vasc Biol.,  2009 Jan;29(1):114-20.
  • Cimino D, Fuso L, Sfiligoi C, Biglia N, Ponzone R, Maggiorotto F, Russo G, Cicatiello L, Weisz A, Taverna D, Sismondi P, De Bortoli M. IDENTIFICATION OF NEW GENES ASSOCIATED WITH BREAST CANCER PROGRESSION BY GENE EXPRESSION ANALYSIS OF PREDEFINED SETS OF NEOPLASTIC TISSUES. Int J Cancer. 2008 Sep 15;123(6):1327-38.
  • Orso F, Penna E, Cimino D, Astanina E, Maione F, Valdembri D, Giraudo E, Serini G, Sismondi P, De Bortoli M, Taverna D. AP-2ALPHA AND AP-2GAMMA REGULATE TUMOR PROGRESSION VIA SPECIFIC GENETIC PROGRAMS. FASEB J. 2008 Aug;22(8):2702-14. Epub 2008 Apr 28.
  • Orso F, Fassetta M, Penna E, Solero A, De Filippo K, Sismondi P, De Bortoli M, Taverna D. THE AP-2ALPHA TRANSCRIPTION FACTOR REGULATES TUMOR CELL MIGRATION AND APOPTOSIS. Adv Exp Med Biol. 2007;604:87-95.
  • Taverna D, Crowley D, Connolly M, Bronson RO and Richard Hynes. (2005). A DIRECT TEST OF POTENTIAL ROLES FOR BETA3 AND BETA5 INTEGRINS IN GROWTH AND METASTASIS OF MURINE MAMMARY CARCINOMAS. Cancer Res. Nov 15; 65(22):10324-9.
  • Taverna D, Moher H, Crowley D, Borsig L, Varki A, Hynes RO. (2004). INCREASED PRIMARY TUMOR GROWTH IN MICE NULL FOR BETA3- OR BETA3/BETA5-INTEGRINS OR SELECTINS. Proc Natl Acad Sci U S A. 2004 Jan 20;101(3):763-8.
  • Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM.Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med. 2002 Jan;8(1):27-34.

Multiple Myeloma (MM)

MASSAIA Prof. Massimo

COSCIA Dott. Marta

Piattaforme di segnalazione in cellule normali e trasformate

DEFILIPPI Prof. Paola
TURCO Prof. Emilia

Ruolo delle dinamiche del citoscheletro nella proliferazione e nel differenziamento dei precursori neuronali

DI CUNTO Prof. Ferdinando

Ruolo delle PI3K

HIRSCH Prof. Emilio

GHIGO Dott. Alessandra

Trapianto di cellule staminali emopoietiche

BRUNO Prof. Benedetto

GIACCONE Dott. Luisa

Unità di Biologia Computazionale

PROVERO Prof Paolo

 

Valutazione molecolare della malattia minima residua nei linfomi non-Hodgkin

Federica Cavallo

Vie di segnalazione implicate nella trasformazione, progressione e resistenza tumorale

CABODI Prof. Sara 

Location: https://www.dbmss.unito.it/robots.html
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