Dipartimento di Biotecnologie Molecolari e Scienze per la Salute

Pubblicazioni selezionate

Costa C, Ebi H, Martini M, Beausoleil SA, Faber AC, Jakubik CT, Huang A, Wang Y, Nishtala M, Hall B, Rikova K, Zhao J, Hirsch E, Benes CH, Engelman JA (2015)
Measurement of PIP3 levels reveals an unexpected role for p110? in early adaptive responses to p110?-specific inhibitors in luminal breast cancer.
https://iris.unito.it/handle/2318/155769

Moretto N, Caruso P, Bosco R, Marchini G, Pastore F, Armani E, Amari G, Rizzi A, Ghidini E, De Fanti R, Capaldi C, Carzaniga L, Hirsch E, Buccellati C, Sala A, Carnini C, Patacchini R, Delcanale M, Civelli M, Villetti G, Facchinetti F (2015)
CHF6001 I: a novel highly potent and selective phosphodiesterase 4 inhibitor with robust anti-inflammatory activity and suitable for topical pulmonary administration.
https://iris.unito.it/handle/2318/155770

Li M, Hirsch E (2015)
Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis.
https://iris.unito.it/handle/2318/157367

Di Savino A, Panuzzo C, Rocca S, Familiari U, Piazza R, Crivellaro S, Carrà G, Ferretti R, Fusella F, Giugliano E, Camporeale A, Franco I, Miniscalco B, Cutrin JC, Turco E, Silengo L, Hirsch E, Rege-Cambrin G, Gambacorti-Passerini C, Pandolfi PP, Papotti M, Saglio G, Tarone G, Morotti A, Brancaccio M (2015)
Morgana acts as an oncosuppressor in chronic myeloid leukemia.
https://iris.unito.it/handle/2318/155771

D', Andrea, Ivana, Fardella, Valentina, Fardella, Stefania, Pallante, Fabio, Ghigo, Alessandra, Iacobucci, Roberta, Maffei, Angelo, Hirsch, Emilio, Lembo, Giuseppe, Carnevale, Daniela (2015)
Lack of kinase-independent activity of PI3K? in locus coeruleus induces ADHD symptoms through increased CREB signaling.
https://iris.unito.it/handle/2318/1523662

Kalish, Brian T, Matte, Alessandro, Andolfo, Immacolata, Iolascon, Achille, Weinberg, Olga, Ghigo, Alessandra, Cimino, James, Siciliano, Angela, Hirsch, Emilio, Federti, Enrica, Puder, Mark, Brugnara, Carlo, De Franceschi, Lucia (2015)
Dietary ?-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.
https://iris.unito.it/handle/2318/1523663

Campa, Carlo C, Ciraolo, Elisa, Ghigo, Alessandra, Germena, Giulia, Hirsch, Emilio (2015)
Crossroads of PI3K and Rac pathways.
https://iris.unito.it/handle/2318/1523665

Galluzzo, Maria, Ciraolo, Elisa, Lucattelli, Monica, Hoxha, Eriola, Ulrich, Martina, Campa, Carlo Cosimo, Lungarella, Giuseppe, Doring, Gerd, Zhou-Suckow, Zhe, Mall, Marcus, Hirsch, Emilio, De Rose, Virginia (2015)
Genetic deletion and pharmacological inhibition of PI3K ? reduces neutrophilic airway inflammation and lung damage in mice with cystic fibrosis-like lung disease.
https://iris.unito.it/handle/2318/1523339

Shymanets, Aliaksei, Prajwal, Null, Vadas, Oscar, Czupalla, Cornelia, Lopiccolo, Jaclyn, Brenowitz, Michael, Ghigo, Alessandra, Hirsch, Emilio, Krause, Eberhard, Wetzker, Reinhard, Williams, Roger L , Harteneck, Christian, Nürnberg, Bernd (2015)
Different inhibition of G??-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a G??-dependent regulator of PI3K? enzymatic activity.
https://iris.unito.it/handle/2318/1523666

Zhang, Min, Prosser, Benjamin L , Bamboye, Moradeke A , Gondim, Antonio N S , Santos, Celio X , Martin, Daniel, Ghigo, Alessandra, Perino, Alessia, Brewer, Alison C , Ward, Christopher W , Hirsch, Emilio, Lederer, W Jonathan, Shah, Ajay M (2015)
Contractile Function during Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.
https://iris.unito.it/handle/2318/1523667

Ghigo A, Franco I, Morello F, Hirsch E (2014)
Myocyte signalling in leucocyte recruitment to the heart.
https://iris.unito.it/handle/2318/143241

Hirsch E, Ghigo A (2014)
Elastin degradation and ensuing inflammation as emerging keys to atherosclerosis.
https://iris.unito.it/handle/2318/143240

Franco I, Gulluni F, Campa CC, Costa C, Margaria JP, Ciraolo E, Martini M, Monteyne D, De Luca E, Germena G, Posor Y, Maffucci T, Marengo S, Haucke V, Falasca M, Perez-Morga D, Boletta A, Merlo GR, Hirsch E (2014)
PI3K Class II ? Controls Spatially Restricted Endosomal PtdIns3P and Rab11 Activation to Promote Primary Cilium Function.
https://iris.unito.it/handle/2318/143910

Unsöld B, Kaul A, Sbroggiò M, Schubert C, Regitz-Zagrosek V, Brancaccio M, Damilano F, Hirsch E, Van Bilsen M, Munts C, Sipido K, Bito V, Detre E, Wagner NM, Schäfer K, Seidler T, Vogt J, Neef S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura-Clapier R, Garnier A, Eschenhagen T, El-Armouche A, Knöll R, Tarone G, Hasenfuß G (2014)
Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction.
https://iris.unito.it/handle/2318/141934

Tarone G, Balligand JL, Bauersachs J, Clerk A, De Windt L, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Knöll R, Leite-Moreira AF, Lourenço AP, Mayr M, Thum T, Tocchetti CG (2014)
Targeting myocardial remodelling to develop novel therapies for heart failure: A position paper from the Working Group on Myocardial Function of the European Society of Cardiology.
https://iris.unito.it/handle/2318/143238

Ciraolo E, Gulluni F, Hirsch E (2014)
Methods to measure the enzymatic activity of PI3Ks.
https://iris.unito.it/handle/2318/149708

Hirsch E, Ciraolo E, Franco I, Ghigo A, Martini M (2014)
PI3K in cancer-stroma interactions: bad in seed and ugly in soil.
https://iris.unito.it/handle/2318/149709

Perino A, Beretta M, Kili? A, Ghigo A, Carnevale D, Repetto IE, Braccini L, Longo D, Liebig-Gonglach M, Zaglia T, Iacobucci R, Mongillo M, Wetzker R, Bauer M, Aime S, Vercelli A, Lembo G, Pfeifer A, Hirsch E (2014)
Combined inhibition of PI3K? and PI3K? reduces fat mass by enhancing ?-MSH-dependent sympathetic drive.
https://iris.unito.it/handle/2318/156874

Beretta M, Bauer M, Hirsch E (2014)
PI3K signaling in the pathogenesis of obesity: The cause and the cure.
https://iris.unito.it/handle/2318/155768

Fan CW, Chen B, Franco I, Lu J, Shi H, Wei S, Wang C, Wu X, Tang W, Roth MG, Williams NS, Hirsch E, Chen C, Lum L (2014)
The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation.
https://iris.unito.it/handle/2318/155767

Hirsch E, Nagai R, Thum T (2014)
Heterocellular signalling and crosstalk in the heart in ischaemia and heart failure.
https://iris.unito.it/handle/2318/143948

Barutta F, Grimaldi S, Franco I, Bellini S, Gambino R, Pinach S, Corbelli A, Bruno G, Rastaldi MP, Aveta T, Hirsch E, Di Marzo V, Gruden G (2014)
Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice.
https://iris.unito.it/handle/2318/154816

Frister A, Schmidt C, Schneble N, Brodhun M, Gonnert FA, Bauer M, Hirsch E, Müller JP, Wetzker R, Bauer R (2014)
Phosphoinositide 3-kinase ? affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells.
https://iris.unito.it/handle/2318/155764

Augusta Di Savino, Cristina Panuzzo, Stefania Rocca, Ubaldo Familiari, Roberta Ferretti, Federica Fusella, Rocco Piazza, Carlo Gambacorti Passerini, Emilia Giuliano, Sabrina Crivellaro, Giovanna Carrà, Annalisa Camporeale, Barbara Miniscalco, Juan Carlos Cutrin, Emilia Turco, Lorenzo Silengo, Emilio Hirsch, Mauro Papotti, Pier Paolo Pandolfi, Giuseppe Saglio, Guido Tarone, Alessandro Morotti, Mara Brancaccio (2014)
Morgana is a new oncosuppressor in CML.
https://iris.unito.it/handle/2318/148912

Leite-Moreira AF, Lourenço AP, Balligand JL, Bauersachs J, Clerk A, De Windt LJ, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Kaminski KA, Knöll R, Mayr M, Tarone G, Thum T, Tocchetti CG (2014)
ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.
https://iris.unito.it/handle/2318/143239

Smirnova NF, Gayral S, Pedros C, Loirand G, Vaillant N, Malet N, Kassem S, Calise D, Goudounèche D, Wymann MP, Hirsch E, Gadeau AP, Martinez LO, Saoudi A, Laffargue M (2014)
Targeting PI3K? activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.
https://iris.unito.it/handle/2318/155765

Lupia E, Pigozzi L, Goffi A, Hirsch E, Montrucchio G (2014)
Role of phosphoinositide 3-kinase in the pathogenesis of acute pancreatitis.
https://iris.unito.it/handle/2318/155766

Martini M, De Santis MC, Braccini L, Gulluni F, Hirsch E (2014)
PI3K/AKT signaling pathway and cancer: an updated review.
https://iris.unito.it/handle/2318/154723

Hirsch E, Novelli F (2014)
Cancer: natural-born killers unleashed.
https://iris.unito.it/handle/2318/157868

Perino A , Beretta M , Kilic A , Ghigo A , Carnevale D , Repetto I E , Braccini L , Longo D , Liebig-Gonglach M , Zaglia T , Iacobucci R , Mongillo M , Wetzker R , Bauer M , Aime S , Vercelli A , Lembo G , Pfeifer A , Hirsch E (2014)
Combined inhibition of PI3K? and PI3K? reduces fat mass by enhancing ?-MSH-dependent sympathetic drive.
https://iris.unito.it/handle/2318/154185

Miriam Martini, Elisa Ciraolo, Federico Gulluni, Emilio Hirsch (2013)
Targeting PI3K in Cancer: Any Good News?
https://iris.unito.it/handle/2318/133138

Posor Y, Eichhorn-Gruenig M, Puchkov D, Schöneberg J, Ullrich A, Lampe A, Müller R, Zarbakhsh S, Gulluni F, Hirsch E, Krauss M, Schultz C, Schmoranzer J, Noé F, Haucke V (2013)
Spatiotemporal control of endocytosis by phosphatidylinositol-3,4-bisphosphate.
https://iris.unito.it/handle/2318/143192

Fumagalli L, Campa CC, Germena G, Lowell CA, Hirsch E, Berton G (2013)
Class I Phosphoinositide-3-Kinases and Src Kinases Play a Nonredundant Role in Regulation of Adhesion-Independent and -Dependent Neutrophil Reactive Oxygen Species Generation.
https://iris.unito.it/handle/2318/143196

Hirsch E, Hilfiker-Kleiner D, Balligand JL, Tarone G, De Windt L, Bauersachs J, Ferdinandy P, Davidson S, Hausenloy DJ, Schulz R (2013)
Interaction of the heart and its close and distant neighbours: report of the Meeting of the ESC Working Groups Myocardial Function and Cellular Biology.
https://iris.unito.it/handle/2318/143190

Collmann E, Bohnacker T, Marone R, Dawson J, Rehberg M, Stringer R, Krombach F, Burkhart C, Hirsch E, Hollingworth GJ, Thomas M, Wymann MP (2013)
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.
https://iris.unito.it/handle/2318/143193

Walser R, Burke JE, Gogvadze E, Bohnacker T, Zhang X, Hess D, Küenzi P, Leitges M, Hirsch E, Williams RL, Laffargue M, Wymann MP (2013)
PKC? phosphorylates PI3K? to activate it and release it from GPCR control.
https://iris.unito.it/handle/2318/143191

Schmid MC, Franco I, Kang SW, Hirsch E, Quilliam LA, Varner JA (2013)
PI3-kinase ? promotes Rap1a-mediated activation of myeloid cell integrin ?4?1, leading to tumor inflammation and growth.
https://iris.unito.it/handle/2318/143194

Hirsch E (2013)
Two signalling hands for uPAR.
https://iris.unito.it/handle/2318/143198

G Germena, E Hirsch (2013)
PI3Ks and small GTPases in neutrophil migration: Two sides of the same coin.
https://iris.unito.it/handle/2318/132167

Zhang M, Perino A, Ghigo A, Hirsch E, Shah AM (2013)
NADPH Oxidases in Heart Failure: Poachers or Gamekeepers?
https://iris.unito.it/handle/2318/129748

Suk HY, Zhou C, Yang TT, Zhu H, Yu RY, Olabisi O, Yang X, Brancho D, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Lefer DJ, Molkentin JD, Ghigo A, Hirsch E, Jin J, Chow CW (2013)
Ablation of Calcineurin A? Reveals Hyperlipidemia and Signaling Cross-talks with Phosphodiesterases.
https://iris.unito.it/handle/2318/131241

Ghigo A, Morello F, Perino A, Hirsch E (2013)
Therapeutic applications of PI3K inhibitors in cardiovascular diseases.
https://iris.unito.it/handle/2318/143195

Zotes TM, Arias CF, Fuster JJ, Spada R, Pérez-Yagüe S, Hirsch E, Wymann M, Carrera AC, Andrés V, Barber DF (2013)
PI3K p110? deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions.
https://iris.unito.it/handle/2318/143242

Sperandio M, Hirsch E (2013)
Editorial to the SI Leukocyte Adhesion and Migration.
https://iris.unito.it/handle/2318/143197

Vinchi F , De Franceschi L , Ghigo A , Townes T , Cimino J , Silengo L , Hirsch E , Altruda F , Tolosano E (2013)
Hemopexin Therapy Improves Cardiovascular Function by Preventing Heme-Induced Endothelial Toxicity in Mouse Models of Hemolytic Diseases.
https://iris.unito.it/handle/2318/132766

Cipolla L, Consonni A, Guidetti G, Canobbio I, Okigaki M, Falasca M, Ciraolo E, Hirsch E, Balduini C, Torti M (2013)
The proline-rich tyrosine kinase Pyk2 regulates platelet integrin ?IIb?3 outside-in signaling.
https://iris.unito.it/handle/2318/132285

Braccini L, Ciraolo E, Martini M, Pirali T, Germena G, Rolfo K, Hirsch E (2012)
PI3K keeps the balance between metabolism and cancer.
https://iris.unito.it/handle/2318/133722

Giovanni Sorba, Gian Cesare Tron, Tracey Pirali, Ubaldina Galli, Alberto Massarotti, Emilio Hirsch, Elisa Ciraolo (2012)
QUINOLIN-4 (1H) -ONE DERIVATIVES AS INHIBITORS OF PHOSPHATIDYLINOSITOL 3-KINASES.
https://iris.unito.it/handle/2318/101745

Noghero A, Perino A, Seano G, Saglio E, Lo Sasso G, Veglio F, Primo L, Hirsch E, Bussolino F, Morello F (2012)
Liver X Receptor Activation Reduces Angiogenesis by Impairing Lipid Raft Localization and Signaling of Vascular Endothelial Growth Factor Receptor-2.
https://iris.unito.it/handle/2318/106537

Consonni A, Cipolla L, Guidetti G, Canobbio I, Ciraolo E, Hirsch E, Falasca M, Okigaki M, Balduini C, Torti M (2012)
Role and regulation of phosphatidylinositol 3-kinase ? in platelet integrin ?2?1 signaling.
https://iris.unito.it/handle/2318/129709

Hirsch E (2012)
Inflaming attraction by RNA.
https://iris.unito.it/handle/2318/129711

Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM (2012)
Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception.
https://iris.unito.it/handle/2318/129712

Perino A, Ghigo A, Scott JD, Hirsch E (2012)
Anchoring proteins as regulators of signaling pathways.
https://iris.unito.it/handle/2318/129746

Hirsch E, Chiarle R (2012)
Calming down T cell acute leukemia.
https://iris.unito.it/handle/2318/130991

Bergamini G, Bell K, Shimamura S, Werner T, Cansfield A, Müller K, Perrin J, Rau C, Ellard K, Hopf C, Doce C, Leggate D, Mangano R, Mathieson T, O', Mahony A, Plavec I, Rharbaoui F, Reinhard F, Savitski MM, Ramsden N, Hirsch E, Drewes G, Rausch O, Bantscheff M, Neubauer G (2012)
A selective inhibitor reveals PI3K? dependence of T(H)17 cell differentiation.
https://iris.unito.it/handle/2318/129707

Ghigo A, Morello F, Perino A, Hirsch E (2012)
Phosphoinositide 3-kinases in health and disease.
https://iris.unito.it/handle/2318/132888

Ghigo A, Perino A, Hirsch E (2012)
Phosphoinositides and cardiovascular diseases.
https://iris.unito.it/handle/2318/129710

Ghigo A, Perino A, Mehel H, Zahradníková A Jr, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, Conti M, Gomez AM, Vandecasteele G, Hirsch E, Fischmeister R (2012)
Phosphoinositide 3-kinase ? protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases.
https://iris.unito.it/handle/2318/132734

Ciraolo E, Perino A, Hirsch E (2012)
Measuring PI3K lipid kinase activity.
https://iris.unito.it/handle/2318/129708

Roller A, Perino A, Dapavo P, Soro E, Okkenhaug K, Hirsch E, Ji H (2012)
Blockade of phosphatidylinositol 3-kinase (PI3K)? or PI3K? reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis.
https://iris.unito.it/handle/2318/129747

Carnevale D, Vecchione C, Mascio G, Esposito G, Cifelli G, Martinello K, Landolfi A, Selvetella G, Grieco P, Damato A, Franco E, Haase H, Maffei A, Ciraolo E, Fucile S, Frati G, Mazzoni O, Hirsch E, Lembo G (2012)
PI3K? INHIBITION REDUCES BLOOD PRESSURE BY A VASORELAXANT AKT/LTCC MECHANISM.
https://iris.unito.it/handle/2318/91700

Martin D, Galisteo R, Molinolo AA, Wetzker R, Hirsch E, Gutkind JS (2011)
PI3K? mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.
https://iris.unito.it/handle/2318/91735

Witko-Sarsat V, Pederzoli-Ribeil M, Hirsch E, Sozzani S, Cassatella MA (2011)
Regulating neutrophil apoptosis: new players enter the game.
https://iris.unito.it/handle/2318/89173

Ciraolo E, Morello F, Hirsch E (2011)
Present and future of PI3K pathway inhibition in cancer: perspectives and limitations.
https://iris.unito.it/handle/2318/92409

Ognibene M, Barbieri O, Vanni C, Mastracci L, Astigiano S, Emionite L, Salani B, Fedele M, Resaz R, Tenca C, Fais F, Sabatini F, De Santanna A, Altruda F, Varesio L, Hirsch E, Eva A (2011)
High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice.
https://iris.unito.it/handle/2318/89676

Ghigo A, Morello F, Perino A, Damilano F, Hirsch E (2011)
Specific PI3K Isoform Modulation in Heart Failure: Lessons from Transgenic Mice.
https://iris.unito.it/handle/2318/88965

Lu XY, Ciraolo E, Stefenia R, Chen GQ, Zhang Y, Hirsch E (2011)
Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines.
https://iris.unito.it/handle/2318/89172

Eschenhagen T, Force T, Ewer MS, de Keulenaer GW, Suter TM, Anker SD, Avkiran M, de Azambuja E, Balligand JL, Brutsaert DL, Condorelli G, Hansen A, Heymans S, Hill JA, Hirsch E, Hilfiker-Kleiner D, Janssens S, de Jong S, Neubauer G, Pieske B, Ponikowski P, Pirmohamed M, Rauchhaus M, Sawyer D, Sugden PH, Wojta J, Zannad F, Shah AM (2011)
Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology.
https://iris.unito.it/handle/2318/89100

Sbroggiò M, Carnevale D, Bertero A, Cifelli G, De Blasio E, Mascio G, Hirsch E, Bahou WF, Turco E, Silengo L, Brancaccio M, Lembo G, Tarone G (2011)
IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload.
https://iris.unito.it/handle/2318/88885

Guasconi M, Lu X, Massarotti A, Caldarelli A, Ciraolo E, Tron GC, Hirsch E, Sorba G, Pirali T (2011)
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors.
https://iris.unito.it/handle/2318/91591

Schmid MC, Avraamides CJ, Dippold HC, Franco I, Foubert P, Ellies LG, Acevedo LM, Manglicmot JR, Song X, Wrasidlo W, Blair SL, Ginsberg MH, Cheresh DA, Hirsch E, Field SJ, Varner JA (2011)
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3k?, a single convergent point promoting tumor inflammation and progression.
https://iris.unito.it/handle/2318/91736

Costa C, Martin-Conte EL, Hirsch E (2011)
Phosphoinositide 3-kinase p110? in immunity.
https://iris.unito.it/handle/2318/91701

Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E (2011)
Integrating Cardiac PIP(3) and cAMP Signaling through a PKA Anchoring Function of p110?.
https://iris.unito.it/handle/2318/87366

Costa C, Germena G, Martin-Conte EL, Molineris I, Bosco E, Marengo S, Azzolino O, Altruda F, Ranieri VM, Hirsch E (2011)
The RacGAP ArhGAP15 is a master negative regulator of neutrophil functions.
https://iris.unito.it/handle/2318/88771

Damilano F, Franco I, Perrino C, Schaefer K, Azzolino O, Carnevale D, Cifelli G, Carullo P, Ragona R, Ghigo A, Perino A, Lembo G, Hirsch E (2011)
Distinct Effects of Leukocyte and Cardiac Phosphoinositide 3-Kinase {gamma} Activity in Pressure Overload-Induced Cardiac Failure.
https://iris.unito.it/handle/2318/82365

Spiller F, Costa C, Souto FO, Vinchi F, Mestriner FL, Laure HJ, Alves-Filho JC, Freitas A, Rosa JC, Ferreira SH, Altruda F, Hirsch E, Greene LJ, Tolosano E, Cunha FQ (2011)
Inhibition of Neutrophil Migration by Hemopexin Leads to IncreasedMortality Due to Sepsis in Mice.
https://iris.unito.it/handle/2318/82019

Elisa Ciraolo, Fulvio Morello, Manuela Iezzi, Romina Marone, Fiorella Altruda, Piero Musiani, Thomas Ruckle, Matthias Wymann, Emilio Hirsch (2010)
Requirement of PI3Kbeta catalytic activity during spermatogenesis.
https://iris.unito.it/handle/2318/72859

Costa C, Hirsch E (2010)
More Than Just Kinases: The Scaffolding Function of PI3K.
https://iris.unito.it/handle/2318/74765

Elisa Ciraolo, Fulvio Morello, Robin M Hobbs, Frieder Wolf, Romina Marone, Manuela Iezzi, Xiaoyun Lu, Giulio Mengozzi, Fiorella Altruda, Giovanni Sorba, Kaomei Guan, Pier Paolo Pandolfi, Matthias P Wymann, Emilio Hirsch (2010)
Essential Role of the p110? Subunit of Phosphoinositide 3-OH Kinase in Male Fertility.
https://iris.unito.it/handle/2318/72513

Otero K, Vecchi A, Hirsch E, Kearley J, Vermi W, Del Prete A, Gonzalvo-Feo S, Garlanda C, Azzolino O, Salogni L, Lloyd CM, Facchetti F, Mantovani A, Sozzani S (2010)
Nonredundant role of CCRL2 in lung dendritic cell trafficking.
https://iris.unito.it/handle/2318/79293

Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B (2010)
PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway.
https://iris.unito.it/handle/2318/76979

Mueller H, Stadtmann A, Van Aken H, Hirsch E, Wang D, Ley K, Zarbock A (2010)
Tyrosine kinase Btk regulates E-selectin-mediated integrin activation andneutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways.
https://iris.unito.it/handle/2318/73894

van Dop WA, Marengo S, Te Velde AA, Ciraolo E, Franco I, Ten Kate FJ, , Boeckxstaens GE, Hardwick JC, Hommes DW, Hirsch E, van den Brink GR (2010)
The absence of functional PI3Kgamma prevents leukocyte recruitment and amelioratesDSS-induced colitis in mice.
https://iris.unito.it/handle/2318/74657

Beer-Hammer S, Zebedin E, von Holleben M, Alferink J, Reis B, Dresing P, Degrandi D, Scheu S, Hirsch E, Sexl V, Pfeffer K, Nürnberg B, Piekorz RP (2010)
The catalytic PI3K isoforms p110{gamma} and p110{delta} contribute to B cell development and maintenance, transformation, and proliferation.
https://iris.unito.it/handle/2318/77033

Damilano F, Perino A, Hirsch E (2010)
PI3K kinase and scaffold functions in heart.
https://iris.unito.it/handle/2318/75111

Seropian IM, Abbate A, Toldo S, Harrington J, Smithson L, Ockaili R, Mezzaroma E, Damilano F, Hirsch E, Van Tassell BW (2010)
Pharmacological Inhibition of Phosphoinositide 3-Kinase Gamma (PI3K?) Promotes Infarct Resorption and Prevents Adverse Cardiac Remodeling after Myocardial Infarction in Mice.
https://iris.unito.it/handle/2318/79819

Martin EL, Souza DG, Fagundes CT, Amaral FA, Assenzio B, Puntorieri V, Del Sorbo L, Fanelli V, Bosco M, Delsedime L, Pinho JF, Lemos VS, Souto FO, Alves-Filho JC, Cunha FQ, Slutsky AS, Ruckle T, Hirsch E, Teixeira MM, Ranieri VM (2010)
Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.
https://iris.unito.it/handle/2318/132490

Fanelli V, Puntorieri V, Assenzio B, Martin EL, Elia V, Bosco M, Delsedime L, Del Sorbo L, Ferrari A, Italiano S, Ghigo A, Slutsky AS, Hirsch E, Ranieri VM (2010)
Pulmonary-derived phosphoinositide 3-kinase gamma (PI3K?) contributes to ventilator-induced lung injury and edema.
https://iris.unito.it/handle/2318/75790

Siragusa M, Katare R, Meloni M, Damilano F, Hirsch E, Emanueli C, Madeddu P (2010)
Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing ofexperimental myocardial infarction in mice.
https://iris.unito.it/handle/2318/77832

Ghigo A, Damilano F, Braccini L, Hirsch E (2010)
PI3K inhibition in inflammation:Toward tailored therapies for specific diseases.
https://iris.unito.it/handle/2318/74729

Giovanni SORBA, Gian Cesare TRON, Tracey PIRALI, Ubaldina GALLI, Alberto MASSAROTTI, Emilio HIRSCH, Elisa CIRAOLO (2010)
Inhibitors of Phosphatidylinositol 3-Kinases, compositions and uses thereof.
https://iris.unito.it/handle/2318/81932

Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY (2010)
Loss of PI3K? enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.
https://iris.unito.it/handle/2318/78883

Costa C, Germena G, Hirsch E (2010)
Dissection of the interplay between class I PI3Ks and Rac signaling in phagocytic functions.
https://iris.unito.it/handle/2318/81238

Ferretti R, Palumbo V, Di Savino A, Velasco S, Sbroggiò M, Sportoletti P, Micale L, Turco E, Silengo L, Palumbo G, Hirsch E, Teruya-Feldstein J, Bonaccorsi S, Pandolfi PP, Gatti M, Tarone G, Brancaccio M (2010)
Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis.
https://iris.unito.it/handle/2318/74409

Roetto A, Di Cunto F, Pellegrino RM, Hirsch E, Azzolino O, Bondi A, Defilippi I, Carturan S, Miniscalco B, Riondato F, Cilloni D, Silengo L, Altruda F, Camaschella C, Saglio G (2010)
Comparison of 3 Tfr2-deficient murine models suggestsdistinct functions for Tfr2-alpha and Tfr2-beta isoforms in different tissues.
https://iris.unito.it/handle/2318/74802

Braccini L, Ciraolo E, Morello F, Lu X, Hirsch E (2009)
PI3K signaling: a crossroads of metabolic regulation.
https://iris.unito.it/handle/2318/72387

Fanelli V, Ciraolo E, Bosco M, Delsedime L, Mensa A, Martin EL, Del sorbo L, Assenzio B, Campanari ML, Hirsch E, Ranieri VM (2009)
PHOSPHOINOSITIDE 3 KINASE BETA ATTENUATES INFLAMMATION AND FIBROSIS IN A BLEOMYCIN MODEL OF ACUTE LUNG INJURY.
https://iris.unito.it/handle/2318/135432

Martin EL, Faggiano C, Campanari ML, Assenzio B, Fanelli V, Del Sorbo L, Hirsch E, Ranieri VM (2009)
PHOSPHOINOSITIDE-3 KINASE GAMMA ACTIVITY CONTRIBUTES TO BACTERIAL DISSEMINATION DURING ABDOMINAL SEPSIS.
https://iris.unito.it/handle/2318/135404

Hirsch E, Braccini L, Ciraolo E, Morello F, Perino A (2009)
Twice upon a time: PI3K's secret double life exposed.
https://iris.unito.it/handle/2318/61479

Morello F, Perino A, Hirsch E (2009)
Phosphoinositide 3-kinase signalling in the vascular system.
https://iris.unito.it/handle/2318/63722

Heymans S, Hirsch E, Anker SD, Aukrust P, Balligand JL, Cohen-Tervaert JW, Drexler H, Filippatos G, Felix SB, Gullestad L, Hilfiker-Kleiner D, Janssens S, Latini R, Neubauer G, Paulus WJ, Pieske B, Ponikowski P, Schroen B, Schultheiss HP, Tschöpe C, Van Bilsen M, Zannad F, McMurray J, Shah AM (2009)
Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology.
https://iris.unito.it/handle/2318/61397

Thomas M, Edwards MJ, Sawicka E, Duggan N, Hirsch E, Wymann MP, Owen C, Trifilieff A, Walker C, Westwick J, Finan P (2009)
Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.
https://iris.unito.it/handle/2318/56503

PIZZI M, HIRSCH E, COSTA C, VITIELLO E (2009)
MICRO-FLUIDIC DEVICE FOR MEASUREMENTS OF CELL MIGRATION IN RESPONSE TO CHEMICAL STIMULI.
https://iris.unito.it/handle/2318/75672

Barberis L, Pasquali C, Bertschy-Meier D, Cuccurullo A, Costa C, Ambrogio C, Vilbois F, Chiarle R, Wymann M, Altruda F, Rommel C, Hirsch E (2009)
Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin.
https://iris.unito.it/handle/2318/60729

Canobbio I, Stefanini L, Cipolla L, Ciraolo E, Gruppi C, Balduini C, Hirsch E, Torti M (2009)
Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM-and integrin-mediated signaling in platelets.
https://iris.unito.it/handle/2318/63611

Brancaccio M, Turco E, Hirsch E (2009)
Tissue-specific KO of ECM proteins.
https://iris.unito.it/handle/2318/62354

Bohnacker T, Marone R, Collmann E, Calvez R, Hirsch E, Wymann MP (2009)
PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.
https://iris.unito.it/handle/2318/63660

Ghigo A, Hirsch E (2008)
Isoform Selective Phosphoinositide 3-Kinase gamma and delta Inhibitors and Their Therapeutic Potential.
https://iris.unito.it/handle/2318/56379

Fougerat A, Gayral S, Gourdy P, Schambourg A, Rückle T, Schwarz MK, Rommel C, Hirsch E, Arnal JF, Salles JP, Perret B, Breton-Douillon M, Wymann MP, Laffargue M (2008)
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
https://iris.unito.it/handle/2318/58574

Ciraolo E, Iezzi M, Marone R, Marengo S, Curcio C, Costa C, Azzolino O, Gonella C, Rubinetto C, Wu H, Dastrù W, Martin EL, Silengo L, Altruda F, Turco E, Lanzetti L, Musiani P, Rückle T, Rommel C, Backer JM, Forni G, Wymann MP, Hirsch E (2008)
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.
https://iris.unito.it/handle/2318/56211

Hirsch E, Ciraolo E, Ghigo A, Costa C (2008)
Taming the PI3K team to hold inflammation and cancer at bay.
https://iris.unito.it/handle/2318/71957

HAMM J, PULITO R, BENEDETTO S, BARBERIS L, HIRSCH E, POLI V, SILENGO L (2008)
Magnetically enriched bone marrow-derived macrophages loaded in vitro with iron oxide can migrate to inflammation sites in mice.
https://iris.unito.it/handle/2318/23048

E CARBONE (2008)
Calcium channels - An overview.
https://iris.unito.it/handle/2318/27227

BARBERIS L, HIRSCH E (2008)
Targeting phosphoinositide 3-kinase gamma to fight inflammation and more.
https://iris.unito.it/handle/2318/26863

Andrés G, Leali D, Mitola S, Coltrini D, Camozzi M, Corsini M, Belleri M, Hirsch E, Schwendener RA, Christofori G, Alcamí A, Presta M (2008)
A Pro-inflammatory Signature Mediates FGF2-induced Angiogenesis.
https://iris.unito.it/handle/2318/58575

Heller R, Chang Q, Ehrlich G, Hsieh SN, Schoenwaelder SM, Kuhlencordt PJ, Preissner KT, Hirsch E, Wetzker R (2008)
Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.
https://iris.unito.it/handle/2318/58527

GARÇON F, PATTON DT, EMERY JL, HIRSCH E, ROTTAPEL R, SASAKI T, OKKENHAUG K (2008)
CD28 provides T cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.
https://iris.unito.it/handle/2318/34316

Ambrogio C, Voena C, Manazza AD, Martinengo C, Costa C, Kirchhausen T, Hirsch E, Inghirami G, Chiarle R (2008)
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
https://iris.unito.it/handle/2318/57951

Konrad S, Ali SR, Wiege K, Syed SN, Engling L, Piekorz RP, Hirsch E, Nürnberg B, Schmidt RE, Gessner JE (2008)
Phosphoinositide 3-Kinases {gamma} and {delta}, Linkers of Coordinate C5a Receptor-Fc{gamma} Receptor Activation and Immune Complex-induced Inflammation.
https://iris.unito.it/handle/2318/57890

CAMERA P, SCHUBERT V, PELLEGRINO M, BERTO G, VERCELLI A , MUZZI P, HIRSCH E, ALTRUDA F, DOTTI CG, DI CUNTO F (2008)
The RhoA-associated protein Citron-N controls dendritic spine maintenance by interacting with spine-associated Golgi compartments.
https://iris.unito.it/handle/2318/40609

Emilio Hirsch, Elisa Ciraolo, Guido Forni, Claudia Curcio (2008)
Regulation of expression of PI3Kbeta protein in tumors.
https://iris.unito.it/handle/2318/30005

ALCÁZAR I, MARQUÉS M, KUMAR A, HIRSCH E, WYMANN M, CARRERA AC, BARBER DF (2007)
Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation.
https://iris.unito.it/handle/2318/28619

FROSSI B, RIVERA J, HIRSCH E, PUCILLO C (2007)
Selective Activation of Fyn/PI3K and p38 MAPK Regulates IL-4 Production in BMMC under Nontoxic Stress Condition.
https://iris.unito.it/handle/2318/35050

MAUS UA, BACKI M, WINTER C, SRIVASTAVA M, SCHWARZ MK, RÜCKLE T, PATON JC, BRILES D, MACK M, WELTE T, MAUS R, BOHLE RM, SEEGER W, ROMMEL C, HIRSCH E, LOHMEYER J, PREISSNER KT (2007)
Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection.
https://iris.unito.it/handle/2318/34368

NOMBELA-ARRIETA C, MEMPEL T R, SORIANO S F, MAZO I, WYMANN M P, HIRSCH E, MARTÍNEZ-A C, FUKUI Y, VON ANDRIAN U H, STEIN JV (2007)
A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress.
https://iris.unito.it/handle/2318/39338

FERGUSON G J, MILNE L, KULKARNI S, SASAKI T, WALKER S, ANDREWS S, CRABBE T, FINAN P, JONES G, JACKSON S, CAMPS M, ROMMEL C, WYMANN M, E HIRSCH, HAWKINS P, STEPHENS L (2007)
PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.
https://iris.unito.it/handle/2318/37036

JI H, RINTELEN F, WALTZINGER C, BERTSCHY MEIER D, BILANCIO A, PEARCE W, HIRSCH E, WYMANN MP, RÜCKLE T, CAMPS M, VANHAESEBROECK B, OKKENHAUG K, ROMMEL C (2007)
Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.
https://iris.unito.it/handle/2318/34346

KIM N, SAUDEMONT A, WEBB L, CAMPS M, RUCKLE T, HIRSCH E, TURNER M, COLUCCI F (2007)
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion.
https://iris.unito.it/handle/2318/34320

COSTA C, BARBERIS L, AMBROGIO C, MANAZZA AD, PATRUCCO E, AZZOLINO O, NEILSEN PO, CIRAOLO E, ALTRUDA F, PRESTWICH GD, CHIARLE R, WYMANN M, RIDLEY A, HIRSCH E (2007)
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma.
https://iris.unito.it/handle/2318/2102

Madeddu P, Kraenkel N, Barcelos LS, Siragusa M, Campagnolo P, Oikawa A, Caporali A, Herman A, Azzolino O, Barberis L, Perino A, Damilano F, Emanueli C, Hirsch E (2007)
Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions.
https://iris.unito.it/handle/2318/61480

E HIRSCH, C COSTA, E CIRAOLO (2007)
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.
https://iris.unito.it/handle/2318/37110

HIRSCH E (2006)
Signal transduction in inflammation. Perspective clues from the leukocyte-endothelium interface.
https://iris.unito.it/handle/2318/35004

LIONETTI V, LISI A, PATRUCCO E, DE GIULI P, MILAZZO MG, CECI S, WYMANN M, LENA A, GREMIGNI V, FANELLI V, HIRSCH E, RANIERI VM (2006)
Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury.
https://iris.unito.it/handle/2318/34836

PERINO A, GHIGO A, DAMILANO F, HIRSCH E (2006)
Identification of the macromolecular complex responsible for PI3Kgamma-dependent regulation of cAMP levels.
https://iris.unito.it/handle/2318/35051

HIRSCH E, LEMBO G, MONTRUCCHIO G, ROMMEL C, COSTA C, BARBERIS L (2006)
Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.
https://iris.unito.it/handle/2318/38583

CAPPELLO P, FRAONE T, BARBERIS L, COSTA C, HIRSCH E, ELIA AR, CAORSI C, MUSSO T, NOVELLI F, GIOVARELLI M (2006)
CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.
https://iris.unito.it/handle/2318/39981

VECCHIONE C, ARETINI A, MARINO G, BETTARINI U, POULET R, MAFFEI A, SBROGGIO M, PASTORE L, GENTILE MT, NOTTE A, IORIO L, HIRSCH E, TARONE G, LEMBO G (2006)
Selective Rac-1 inhibition protects from diabetes-induced vascular injury.
https://iris.unito.it/handle/2318/38763

BARBER DF, BARTOLOME A, HERNANDEZ C, FLORES JM, FERNANDEZ-ARIAS C, RODRIGUEZ-BORLADO L, HIRSCH E, WYMANN M, BALOMENOS D, CARRERA AC (2006)
Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion.
https://iris.unito.it/handle/2318/37975

A MARCANTONI, R C LEVI, M P GALLO, E HIRSCH, G ALLOATTI (2006)
Phosphoinositide 3-kinasegamma (PI3Kgamma) controls L-type calcium current (ICa,L) through its positive modulation of type-3 phosphodiesterase (PDE3).
https://iris.unito.it/handle/2318/40930

BRANCACCIO M, HIRSCH E, NOTTE A, SELVETELLA G, LEMBO G, TARONE G (2006)
Integrin signalling: The tug-of-war in heart hypertrophy.
https://iris.unito.it/handle/2318/10157

CAMPS M, RUCKLE T, JI H, ARDISSONE V, RINTELEN F, SHAW J, FERRANDI C, CHABERT C, GILLIERON C, FRANCON B, MARTIN T, GRETENER D, PERRIN D, LEROY D, VITTE PA, HIRSCH E, WYMANN MP, CIRILLO R, SCHWARZ MK, ROMMEL C (2005)
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
https://iris.unito.it/handle/2318/40516

WEBB LM, VIGORITO E, WYMANN MP, HIRSCH E, TURNER M (2005)
Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.
https://iris.unito.it/handle/2318/40988

THOMAS MJ, SMITH A, HEAD DH, MILNE L, NICHOLLS A, PEARCE W, VANHAESEBROECK B, WYMANN MP, HIRSCH E, TRIFILIEFF A, WALKER C, FINAN P, WESTWICK J (2005)
Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.
https://iris.unito.it/handle/2318/35082

VECCHIONE C, PATRUCCO E, MARINO G, BARBERIS L, POULET R, ARETINI A, MAFFEI A, GENTILE MT, STORTO M, AZZOLINO O, BRANCACCIO M, COLUSSI GL, BETTARINI U, ALTRUDA F, SILENGO L, TARONE G, WYMANN MP, HIRSCH E, LEMBO G (2005)
Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma.
https://iris.unito.it/handle/2318/38537

MANTOVANI A, GARLANDA C, HIRSCH E (2005)
METHODS AND AGENTS FOR CONTROLLING INTESTINAL INFLAMMATION AND MUCOSAL IMMUNITY USING AGENTS INTERACTING WITH TIR8/SIGIRR.
https://iris.unito.it/handle/2318/78429

AMBROGIO C, VOENA C, MANAZZA AD, PIVA R, RIERA L, BARBERIS L, COSTA C, TARONE G, DEFILIPPI P, HIRSCH E, ERBA EB, MOHAMMED S, JENSEN ON, PALESTRO G, INGHIRAMI G, CHIARLE R (2005)
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.
https://iris.unito.it/handle/2318/53813

CONDLIFFE AM, DAVIDSON K, ANDERSON KE, ELLSON CD, CRABBE T, OKKENHAUG K, VANHAESEBROECK B, TURNER M, WEBB L, WYMANN MP, HIRSCH E, RUCKLE T, CAMPS M, ROMMEL C, JACKSON SP, CHILVERS ER, STEPHENS LR, HAWKINS PT (2005)
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
https://iris.unito.it/handle/2318/40506

FAGOONEE S, GBUREK J, HIRSCH E, MARRO S, MOESTRUP SK, LAURBERG JM, CHRISTENSEN EI, SILENGO L, ALTRUDA F, TOLOSANO E (2005)
Plasma protein haptoglobin modulates renal iron loading.
https://iris.unito.it/handle/2318/40964

ALLOATTI G, MARCANTONI A, LEVI R, GALLO MP, DEL SORBO L, PATRUCCO E, BARBERIS L, MALAN D, AZZOLINO O, WYMANN M, HIRSCH E, MONTRUCCHIO G (2005)
Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level.
https://iris.unito.it/handle/2318/38899

DEL PRETE A, VERMI W, DANDER E, OTERO K, BARBERIS L, LUINI W, BERNASCONI S, SIRONI M, SANTORO A, GARLANDA C, FACCHETTI F, WYMANN MP, VECCHI A, HIRSCH E, MANTOVANI A, SOZZANI S (2004)
Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice.
https://iris.unito.it/handle/2318/38972

SALUSTRI A, GARLANDA C, HIRSCH E, DE ACETIS M, MACCAGNO A, BOTTAZZI B, DONI A, BASTONE A, MANTOVANI G, BECK PECCOZ P, SALVATORI G, MAHONEY DJ, DAY AJ, SIRACUSA G, ROMANI L, MANTOVANI A (2004)
PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization.
https://iris.unito.it/handle/2318/34839

PATRUCCO E, NOTTE A, BARBERIS L, SELVETELLA G, MAFFEI A, BRANCACCIO M, MARENGO S, RUSSO G, AZZOLINO O, RYBALKIN SD, SILENGO L, ALTRUDA F, WETZKER R, WYMANN MP, LEMBO G, HIRSCH E (2004)
PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.
https://iris.unito.it/handle/2318/38418

GARLANDA C, RIVA F, POLENTARUTTI N, BURACCHI C, SIRONI M, DE BORTOLI M, MUZIO M, BERGOTTINI R, SCANZIANI E, VECCHI A, HIRSCH E, MANTOVANI A (2004)
Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family.
https://iris.unito.it/handle/2318/34858

G SELVETELLA, E HIRSCH, A NOTTE, G TARONE, G LEMBO (2004)
Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence.
https://iris.unito.it/handle/2318/36668

ALLOATTI G, MONTRUCCHIO G, LEMBO G, HIRSCH E (2004)
Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease.
https://iris.unito.it/handle/2318/42104

LUPIA E, GOFFI A, DE GIULI P, AZZOLINO O, BOSCO O, PATRUCCO E, VIVALDO MC, RICCA M, WYMANN MP, HIRSCH E, MONTRUCCHIO G, EMANUELLI G (2004)
Ablation of phosphoinositide 3-kinase-gamma reduces the severity of acute pancreatitis.
https://iris.unito.it/handle/2318/39518

WEISS-HALJITI C, PASQUALI C, JI H, GILLIERON C, CHABERT C, CURCHOD ML, HIRSCH E, RIDLEY AJ, VAN HUIJSDUIJNEN RH, CAMPS M, ROMMEL C (2004)
Involvement of phosphoinositide 3-kinase gamma, Rac, and PAK signaling in chemokine-induced macrophage migration.
https://iris.unito.it/handle/2318/39252

WYMANN MP, BJÖRKLÖF K, CALVEZ R, FINAN P, THOMAST M, TRIFILIEFF A, BARBIER M, F ALTRUDA, HIRSCH E , LAFFARGUE M (2003)
Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy.
https://iris.unito.it/handle/2318/38589

ROTH-KLEINER M, HIRSCH E, SCHITTNY JC (2003)
Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture.
https://iris.unito.it/handle/2318/35786

LOVA P , PAGANINI S , HIRSCH E , L BARBERIS, WYMANN M , SINIGAGLIA F , BALDUINI C , TORTI M (2003)
A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.
https://iris.unito.it/handle/2318/37447

BERGER TM, HIRSCH E, DJONOV V, SCHITTNY JC (2003)
Loss of beta1-integrin-deficient cells during the development of endoderm-derived epithelia.
https://iris.unito.it/handle/2318/34873

JONES G E , PRIGMORE E , DUNN G A , E HIRSCH, WYMANN M P , RIDLEY A J (2003)
Requirement for PI 3-kinase gamma in macrophage migration to MCP-1 and CSF-1.
https://iris.unito.it/handle/2318/37688

LOVA P , PAGANINI P , E HIRSCH, BARBERIS L , WYMANN M P , SINIGAGLIA F , BALDUINI C , TORTI M (2003)
A selective role for phosphatidylinositol(3,4,5)trisphosphate in the Gi-dependent activation of platelet Rap1B.
https://iris.unito.it/handle/2318/6518

L RODRIGUEZ-BORLADO, D F BARBER, C HERNANDEZ, M A RODRIGUEZ-MARCOS, A SANCHEZ, E HIRSCH, M WYMANN, C MARTINEZ-A, A C CARRERA (2003)
Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio.
https://iris.unito.it/handle/2318/42494

BRANCACCIO M , FRATTA L , NOTTE A , E HIRSCH, POULET R , GUAZZONE S , DE ACETIS M , VECCHIONE C , MARINO G , ALTRUDA F , SILENGO L , TARONE G (2003)
Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload.
https://iris.unito.it/handle/2318/40474

ALLOATTI G , LEVI R , MALAN D , DEL SORBO L , BOSCO O , BARBERIS L , MARCANTONI A , BEDENDI I , PENNA C , AZZOLINO O , ALTRUDA F , WYMANN M , HIRSCH E , MONTRUCCHIO G (2003)
Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility.
https://iris.unito.it/handle/2318/38198

LAFFARGUE M, CALVEZ R, FINAN P, TRIFILIEFF A, BARBIER M, ALTRUDA F, HIRSCH E, WYMANN MP (2002)
Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function.
https://iris.unito.it/handle/2318/30898

LAFFARGUE M , CALVEZ R , FINAN P , TRIFILIEFF A , BARBIER M , ALTRUDA F , E HIRSCH, WYMANN M P (2002)
Allergic mast cell hyperreactivity needs PI3Kg.
https://iris.unito.it/handle/2318/6506

TOLOSANO E, FAGOONEE S, HIRSCH E, BERGER FG, BAUMANN H, SILENGO L , ALTRUDA F (2002)
Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double null mice after acute hemolysis.
https://iris.unito.it/handle/2318/21755

MALAN D, MARCANTONI A, GALLO MP, BEDENDI I, PENNA C, LEVI RC, HIRSCH E, ALLOATTI G (2002)
Role of PI3K gamma in beta-adrenergic stimulation of cardiac contractility and L-type calcium current.
https://iris.unito.it/handle/2318/51082

HIRSCH E, POZZATO M, VERCELLI A, BARBERIS L, AZZOLINO O, RUSSO C, VANNI C, SILENGO L, EVA A, ALTRUDA F (2002)
Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl.
https://iris.unito.it/handle/2318/40639

HIRSCH E, BARBERIS L, BRANCACCIO M, AZZOLINO O, XU DZ, KYRIAKIS JM, SILENGO L, GIANCOTTI FG, TARONE G, FASSLER R, ALTRUDA F (2002)
Defective Rac-mediated proliferation and survival after targeted mutation of the beta(1) integrin cytodomain.
https://iris.unito.it/handle/2318/1775

E HIRSCH, POZZATO M , VERCELLI A , BARBERIS L , AZZOLINO O , RUSSO C , VANNI C , SILENGO L , EVA A , ALTRUDA F (2002)
Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPases activator Dbl.
https://iris.unito.it/handle/2318/6516

GARLANDA C , E HIRSCH, BOZZA S , SALUSTRI A , DE ACETIS M , NOTA R , MACCAGNO A , RIVA F , BOTTAZZI B , PERI G , DONI A , VAGO L , BOTTO M , DE SANTIS R , CARMINATI P , SIRACUSA G , ALTRUDA F , VECCHI A , ROMANI L , MANTOVANI A (2002)
Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response.
https://iris.unito.it/handle/2318/38550

CRACKOWER M A , OUDIT G Y , KOZIERADZKI I , SARAO R , SUN H , SASAKI T , E HIRSCH, SUZUKI A , SHIOI T , IRIE-SASAKI J , SAH R , CHENG H M , RYBIN V O , LEMBO G , FRATTA L , OLIVEIRA-DOS-SANTOS A J , BENOVIC J L , KAHN R , IZUMO S , STEINBERG S F , WYMANN M P , BACKX P H , PENNINGER J M (2002)
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways.
https://iris.unito.it/handle/2318/40136

CANOBBIO I , BERTONI A , LOVA P , PAGANINI S , E HIRSCH, SINIGAGLIA F , BALDUINI C , TORTI M (2001)
Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and FCgIIA receptor.
https://iris.unito.it/handle/2318/6517

BARBIER M, ATTOUB S, CALVEZ R, LAFFARGUE M, JARRY A, MAREEL M, ALTRUDA F, GESPACH C, WU D, LU B, HIRSCH E, WYMANN MP (2001)
Tumour biology. Weakening link to colorectal cancer?
https://iris.unito.it/handle/2318/30925

BARBIER M, ATTOUB S, CALVEZ R, LAFFARGUE M, MAREEL M, ALTRUDA F, GESPACH C, E HIRSCH, WYMANN M (2001)
Tumor biology: mouse models of colon cancer.
https://iris.unito.it/handle/2318/6505

CANOBBIO I, BERTONI A, LOVA P, PAGANINI S, HIRSCH E, SINIGAGLIA F, BALDUINI C, TORTI M (2001)
Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and Fc gamma IIA receptor.
https://iris.unito.it/handle/2318/33254

ZHOU XH, BRAKEBUSCH C, MATTHIES H, OOHASHI T, HIRSCH E, MOSER M, KRUG M, SEIDENBECHER CI, BOECKERS TM, RAUCH U, BUETTNER R, GUNDELFINGER ED, FÄSSLER R (2001)
Neurocan is dispensable for brain development.
https://iris.unito.it/handle/2318/33226

RAVIZZA T, MONETA D, BOTTAZZI B, PERI G, GARLANDA C, HIRSCH E, RICHARDS GJ, MANTOVANI A, VEZZANI A (2001)
Dynamic induction of the long pentraxin PTX3 in the CNS after limbic seizures: evidence for a protective role in seizure-induced neurodegeneration.
https://iris.unito.it/handle/2318/34226

E HIRSCH, O BOSCO, P TROPEL, M LAFFARGUE, R CALVEZ, F ALTRUDA, M P WYMANN, G MONTRUCCHIO (2001)
Resistance to thromboembolism in PI3-K gamma-deficient mice.
https://iris.unito.it/handle/2318/38659

HIRSCH E, BRANCACCIO M, ALTRUDA F (2000)
Tissue-specific KO of ECM proteins.
https://iris.unito.it/handle/2318/30924

HIRSCH E, KATANAEV VL, GARLANDA C, AZZOLINO O, PIROLA L, SILENGO L, SOZZANI S, MANTOVANI A, ALTRUDA F, WYMANN MP (2000)
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
https://iris.unito.it/handle/2318/30894

E HIRSCH, KATANAEV V L , GARLANDA C , AZZOLINO O , PIROLA L , SILENGO L , SOZZANI S , MANTOVANI A , ALTRUDA F , WYMANN M P (2000)
Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.
https://iris.unito.it/handle/2318/6503

DI CUNTO F, IMARISIO S , HIRSCH E , BROCCOLI V , BULFONE A , MIGHELI A , ATZORI C , TURCO E , TRIOLO R , DOTTO G P , SILENGO L , ALTRUDA F (2000)
Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis.
https://iris.unito.it/handle/2318/37297

WYMANN MP, SOZZANI S, ALTRUDA F, MANTOVANI A, HIRSCH E (2000)
Lipids on the move: phosphoinositide 3-kinases in leukocyte function.
https://iris.unito.it/handle/2318/30923

HIRSCH E, OOHASHI T, AHMAD M, STAMM S, FÄSSLER R (2000)
Peri-implantation lethality in mice lacking the Sm motif-containing protein Lsm4.
https://iris.unito.it/handle/2318/33255

HIRSCH E, M BRANCACCIO, ALTRUDA F (2000)
Tissue-specific KO of ECM proteins.
https://iris.unito.it/handle/2318/11522

G TARONE, E HIRSCH, M BRANCACCIO, M DE ACETIS, L BARBERIS, F BALZAC, S RETTA, C BOTTA, F ALTRUDA, L SILENGO (2000)
Integrin function and regulation in development.
https://iris.unito.it/handle/2318/37997

WYMANN M P , SOZZANI S , ALTRUDA F , MANTOVANI A , E HIRSCH (2000)
Lipids on the move: phosphoinositide 3-kinases in leukocyte function.
https://iris.unito.it/handle/2318/6504

HIRSCH E , WYMANN MP, PATRUCCO E , E TOLOSANO, BULGARELLI-LEVA G , MARENGO S , ROCCHI M , ALTRUDA F (2000)
Analysis of the murine phosphoinositide 3-kinase gamma gene.
https://iris.unito.it/handle/2318/40371

HIRSCH E, CERVELLA P, SILENGO L, ALTRUDA F (1999)
Determination of positive and negative regulatory elements.
https://iris.unito.it/handle/2318/30907

TOLOSANO E, HIRSCH E, PATRUCCO E, CAMASCHELLA C, NAVONE R, SILENGO L, ALTRUDA F (1999)
Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice.
https://iris.unito.it/handle/2318/36754

EMILIO HIRSCH, M BRANCACCIO (1999)
Gli animali transgenici: frontiera tra la ricerca fondamentale e applicata.
https://iris.unito.it/handle/2318/2943

ASZÓDI A, BATEMAN JF, HIRSCH E, BARANYI M, HUNZIKER EB, HAUSER N, BÖSZE Z, FÄSSLER R (1999)
Normal skeletal development of mice lacking matrilin 1: redundant function of matrilins in cartilage?
https://iris.unito.it/handle/2318/33250

BRANCACCIO M, GUAZZONE S, MENINI N, SIBONA E, HIRSCH E, DE ANDREA M, ROCCHI M, ALTRUDA F, TARONE G, SILENGO L (1999)
Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain.
https://iris.unito.it/handle/2318/39062

A CHIOCCHETTI, E TOLOSANO, E HIRSCH, L SILENGO, F ALTRUDA (1997)
Green fluorescent protein as a reporter of gene expression in transgenic mice.
https://iris.unito.it/handle/2318/37966

BRAKEBUSCH C, HIRSCH E, POTOCNIK A, FÄSSLER R (1997)
Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules.
https://iris.unito.it/handle/2318/33251

R FÄSSLER, E GEORGES-LABUESSE, E HIRSCH (1996)
Genetic analyses of integrin function in mice.
https://iris.unito.it/handle/2318/37657

SALMIVIRTA K, GULLBERG D, HIRSCH E, ALTRUDA F, EKBLOM P (1996)
Integrin subunit expression associated with epithelial-mesenchymal interactions during murine tooth development.
https://iris.unito.it/handle/2318/30895

FORSBERG E, HIRSCH E, FRÖHLICH L, MEYER M, EKBLOM P, ASZODI A, WERNER S, FÄSSLER R (1996)
Skin wounds and severed nerves heal normally in mice lacking tenascin-C.
https://iris.unito.it/handle/2318/34776

E HIRSCH, IGLESIAS A , POTOCNIK A J , HARTMANN U , FÄSSLER R (1996)
Impaired migration but not differentiation of haematopoietic stem cells in the absence of beta1 integrins.
https://iris.unito.it/handle/2318/36842

E TOLOSANO, M A CUTUFIA, E HIRSCH, G STEFANUTO, S VOYRON, A FASOLO, L SILENGO, F ALTRUDA (1996)
Ciliary neurotrophic factor constitutively expressed in the nervous system of transgenic mice protects embryonic dorsal root ganglion neurons from apoptosis.
https://iris.unito.it/handle/2318/46411

E TOLOSANO, CURTUFIA M A , HIRSCH E , SILENGO L , ALTRUDA F (1996)
Specific expression in brain and liver driven by the hemopexin promoter in transgenic mice.
https://iris.unito.it/handle/2318/39211

STEFANUTO G , CERRATO M , CHIOCCHETTI A , E TOLOSANO, HIRSCH E , CRISTOFORI R , SILENGO L , ALTRUDA F (1995)
Analysis of regulatory regions of the ciliary neutrophic factor gene in transgenic mice.
https://iris.unito.it/handle/2318/37125

HIRSCH E, GULLBERG D, BALZAC F, ALTRUDA F, SILENGO L, TARONE G (1994)
Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development.
https://iris.unito.it/handle/2318/30951

TARONE G, RUSSO MA, HIRSCH E, ODORISIO T, ALTRUDA F, SILENGO L, SIRACUSA G (1993)
Expression of beta 1 integrin complexes on the surface of unfertilized mouse oocyte.
https://iris.unito.it/handle/2318/30833

HIRSCH E, BALZAC F, PASTORE C, TARONE G, SILENGO L, ALTRUDA F (1993)
The beta 1 integrin distal promoter is developmentally regulated in transgenic mice.
https://iris.unito.it/handle/2318/30830

Insegnamenti

• ADE La segnalazione recettoriale nei processi pato-fisiologici (MED3303)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Basi biologiche (canale A) (SME0881A)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Basi biologiche, molecolari e di genetica umana (canale A) (SME0881)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Biologia applicata (MED3080B)
  Corso di laurea in Igiene Dentale
• C.I. MODELLI PRECLINICI E METODOLOGIE GENOMICHE (SME0895)
  Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9
• COMPUTATIONAL GENOMICS AND GENE NETWORKS (BIO0154 Pds 308-BIDD)
  Master Program in Molecular Biotechnology
• GENETICS MODELS OF HUMAN PATHOLOGY (BIO0187)
  Corso di Laurea in Biotecnologie
• GENETICS MODELS OF HUMAN PATHOLOGY (BIO0187 Pds GEN)
  Master Program in Molecular Biotechnology
• Interactions and Gene Networks (BIO0154B Pds 308-BIDD)
  Master Program in Molecular Biotechnology
• Modelli Genetici di Patologie Umane (BIO0010)
  Corso di Laurea in Biotecnologie
• Modelli sperimentali in ambito biotecnologico (SME0895A)
  Corso di Laurea Magistrale in Biotecnologie Mediche - Classe LM-9
• SCIENTIFIC COMMUNICATION (BIO0120 Pds GEN)
  Master Program in Molecular Biotechnology
• SCIENZE BIOMEDICHE 2 (MED3080)
  Corso di laurea in Igiene Dentale
• Scientific communication (1) (BIO0120A Pds GEN)
  Master Program in Molecular Biotechnology

Temi di ricerca

Per maggiori dettagli è possibile consultare la pagina del Docente sul sito del Dipartimento di Genetica, Biologia e Biochimica

Gruppi di ricerca

Ruolo delle PI3K

 

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Organi

• Research Commission

• Commissione Ricerca
• Consiglio di Dipartimento

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