Activities

Altered metabolism is a general feature of diseased tissues, not only cancer, but also heart failure, stroke etc. Magnetic Resonance Imaging and Spectroscopy are powerful diagnostic tools that allow the non-invasive detection and quantitation of metabolites in vivo and in cells. The main limit to the application of these methods are given by the low sensitivity of MR based spectroscopy. Hyperpolarization techniques lead to the enhancements of MR signals by orders of magnitude. Hyperpolarized pyruvate, obtained through an affordable and easy to handle approach named PHIP-SAH, is applied to the investigation of these metabolic changes. The research focuses also on the development of new derivatives of biologically relevant molecules, and on the optimization of the hyperpolarization procedure

Group

• Dott.ssa Francesca Reineri (PI) Research Fellow
• Eleonora Cavallari, PostDoc
• Carla Carrera, PostDoc
• Oksana Bondar, PhD student
• Ginevra Di Matteo, student