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Development of contrast agents for Image-Guided Therapy procedures

Prof. Terreno Enzo (Principal Investigator)

Activities

Besides the consolidated use of contrast agents for in vivo diagnosis, imaging technologies can offer a valuable contribution to improve therapeutic procedures, including pharmacologic treatment and surgery. This constantly growing research field, better known as Theranostics, can allow the design of protocols where imaging can provide in information on the biodistribution, delivery/release, and therapeutic outcome of a given drug, with a minimal invasiveness and in real-time.

The current research effort of the group is primarily focused on the development of MRI procedures for the visualization of the intratumor release of a chemotherapeutic (e.g. doxorubicin) from MRI-detectable liposomes triggered by the application of low intensity ultrasound.

As far as Image-Guided Surgery is concerned, the classical approach is the design of NIR fluorophores conjugated with targeting vectors (mostly peptides) for specific markers of the disease. Attention is also paid to develop dual agents (e.g. PET/NIRF or MRI/NIRF) where PET (or MRI) detection is used to prepare the intervention and NIRF detection will help surgeons to improve the success of the surgical procedure.

Group

  • AIRC IG project “Boosting the efficacy of liposomal doxorubicin against ovarian cancer by local ultrasound stimulation under MRI guidance”. E. Terreno PI
  • Project “Studio MRI in vivo del ruolo dei linfociti nella progressione della Sclerosi Multipla allo scopo di sviluppare un nuovo trattamento farmacologico” funded by CRT. E. Terreno PI
  • Eu-H2020 project QUIERO (Quantitative MR-based imaging of physical biomarkers) funded by EMPIR programme. Partner
  • Website of the molecular imaging group

 

 

 

 

Ultimo aggiornamento: 08/04/2022 12:41
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