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Translational research in B-Cell Lymphoma




B-Cell Lymphomas are a heterogeneous group of blood cancers that usually respond to treatment but often eventually relapse, conferring to patients a dismal prognosis. This translational research group is working on molecular biomarkers investigation in the context of B-cell lymphoma clinical trials, mainly led by the Fondazione Italiana Linfomi (FIL). Main interests of this group are: identification of baseline prognostic and predictive biomarkers, minimal residual disease (MRD) monitoring, and implementation of non-invasive diagnostic tools (i.e. “liquid biopsy”) in mantle cell lymphoma, follicular lymphoma and Waldenström macroglobulinemia. Main technologies employed are quantitative-Real Time PCR, Droplet Digital PCR and Next Generation Sequencing to target both genomic rearrangements (e.g. immunoglobulin VDJ, Bcl1/IGH, Bcl2/IGH) and mutations (e.g. MYD88, TP53 and others). Finally, as the laboratory involves a recognized collaboration with biomedical engineers, projects on medical informatics applied on translational clinical trials are strongly supported






Ultimo aggiornamento: 08/04/2022 12:20