PI3K signaling in cardiovascular and pulmonary disease
Prof.ssa Alessandra Ghigo (Principal Investigator)
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ActivitiesThe research activity is focused on two main topics:
Study of the molecular mechanisms underlying the cardiotoxicity of anti-cancer treatments, such as radiotherapy and chemotherapy Identification of pharmacological targets for the prevention and the treatment of anti-cancer therapy-related cardiotoxicity, with a major focus on PI3K Identification of new biomarkers of anti-cancer therapy-related cardiotoxicity Study of the molecular mechanisms underlying obstructive (Cystic Fibrosis, Chronic Obstructive Pulmonary Disease, Bronchiectasis) and restrictive (Idiopathic Pulmonary Fibrosis) airway disease Validation of new therapeutic targets for the treatment of obstructive and restrictive airway diseases, with a major focus on PI3K Development of new drugs targeting PI3K for the treatment of obstructive and restrictive airway diseases |
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